The molecular weight of this material is 341,000 daltons. This product is a native fibrinogen that consist of three subunits:
α-chain 63.5 kDa
β-chain 56 kDa
γ chain 47 kDa
Extinction Coefficient (1%) = 15.1
Extinction coefficients are reported for 280 nm using 1 cm path length.
341576-M
Fibrinogen, Human Plasma
Fibrinogen, CAS 9001-32-5, is a soluble plasma glycoprotein that is synthesized in the hepatic parenchymal cells. Contains >90% clottable protein.
Synonim(y):
Fibrinogen, Human Plasma, Coagulation Factor I
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 100 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 356,00 zł | |
| 1 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1850,00 zł |
Informacje o tej pozycji
Form:
lyophilized
Biological source:
human plasma
356,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócbiological source
human plasma
Quality Segment
description
Merck USA index - 14, 4071
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
sterile distilled water: soluble
storage temp.
2-8°C
General description
Do not disturb until the fibrinogen is completely solubilized.
Native fibrinogen from human plasma. A plasma glycoprotein, essential for clotting blood. Synthesized and secreted by hepatic parenchymal cells. Fibrinogen, also known as Coagulation Factor I, is an acute-phase plasma protein found at a concentration of about 300 mg/100 ml. Conversion of soluble fibrinogen to the insoluble clot-forming fibrin is the terminal stage of blood clotting. Clinically, fibrinogen is found at elevated levels during pregnancy, after surgical trauma, or in cases of myocardial infarction, and is decreased in cases of liver cirrhosis and serum hepatitis.
Biochem/physiol Actions
Contains ≥90% clottable proteins.
Physical form
Lyophilized from 20 mM sodium citrate-HCl, pH 7.4.
Preparation Note
Following reconstitution, aliquot and freeze (-70°C). Do not store solutions on ice; precipitation will occur. Stock solutions are stable for up to 6 months at -70°C. Avoid freeze-thaw cycles.
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Protein must be thawed in a 37°C water bath. Solutions used to reconstitute fibrinogen should first be brought to 37°C. Once at 37°C, the solution can be added to the fibrinogen and this mixture should remain at 37°C until the fibrinogen is completely solubilized. If the vial is disturbed before the fibrinogen is completely dissolved, the fibrinogen will precipitate. Please see vial label for lot-specific reconstitution volume.
Analysis Note
homogeneous by SDS-PAGE.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Toxicity: Harmful (C)
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Ta pozycja | |||
|---|---|---|---|
| biological source human plasma | biological source - | biological source human plasma | biological source human plasma |
| form lyophilized | form lyophilized | form lyophilized | form powder |
| solubility sterile distilled water: soluble | solubility sterile distilled water: soluble | solubility water: 25 mg/mL | solubility 0.9% NaCl: soluble |
| storage condition OK to freeze | storage condition OK to freeze | storage condition OK to freeze | storage condition - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 300 |
Klasa składowania
13 - Non Combustible Solids
wgk
WGK 3
Certyfikaty analizy (CoA)
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Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| 341576-100MG | 04055977215083 |
| 341576-1GM | 04055977215076 |
| 341576-1GM-M | 04055977215076 |
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What is the molecular weight and extinction coefficient of this protein ?
1 answer-
Helpful?
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Hello, what is the final concentration when I dilute the Fibrinogen in the given reconstitution volume?
1 answer-
The post-reconstitution concentration for this product is typically 40–50 mg/mL, with most lots resuspended at approximately 45 mg/mL. The reconstitution volume is lot-specific and reported on the vial label and the Certificate of Analysis. Please see the link below to access a lot-specific Certificate:
https://www.sigmaaldrich.com/product/mm/341576m#product-documentationHelpful?
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Is this a blood fraction.
1 answer-
This product is native fibrinogen derived from human plasma. It is a plasma glycoprotein essential for blood clotting and is synthesized and secreted by hepatic parenchymal cells. The preparation is sourced from plasma that has been certified as negative for HBsAg and for antibodies to HIV and HCV.
Helpful?
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