233165

Clioquinol

A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic.

• Synonim(y): Clioquinol, 5-Chloro-7-iodo-8-hydroxyquinoline
• Wzór empiryczny (zapis Hilla): C₉H₅ClINO
• Numer CAS: 130-26-7
• Masa cząsteczkowa: 305.50
• Numer MDL: MFCD00006787
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥95% (HPLC)
• Postać: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• rozpuszczalność: ethanol: 1 mg/mL; methanol: 1.5 mg/mL; DMSO: 20 mg/mL
• Warunki transportu: ambient
• temp. przechowywania: −20°C
• InChI: 1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
• Klucz InChI: QCDFBFJGMNKBDO-UHFFFAOYSA-N

Opis

Opis ogólny

A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid’s ability to clump together, apparently by trapping the Cu²⁺ and Zn²⁺ that stud these deposits. Shown to increase distal dominant axonopathy in animal models.

A metal ion chelator that crosses the blood-brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid′s ability to clump together, apparently by trapping the Cu²⁺ and Zn²⁺ that reduces the build-up of these deposits. Exhibits greater affinity for Cu²⁺ and Zn²⁺ than for Ca²⁺ and Mg²⁺. Shown to induce distal dominant axonopathy in animal models. Clioquinol treatment has been shown to be beneficial in a mouse model of Alzheimer′s disease.

Działania biochem./fizjol.

Cell permeable: no

Primary Target
Metal ion chelator

Product does not compete with ATP.

Reversible: no

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Rekonstytucja

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Inne uwagi

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Melov, S. 2002. Trends Neurosci.25, 121.
Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord.12, 408.
Helmuth, L., et al. 2000. Science290, 1273.
Tateishi, J., et al. 2000. Neuropathology20, Suppl: S20-4.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H301,H315,H317,H319
• Zwroty wskazujące środki ostrożności: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3