212385-M

Carbamoylcholine chloride

≥98% (titration), nicotinic and muscarinic receptor agonist, solid (fine crystalline)

• Synonim(y): Carbachol, Carbamoylcholine Chloride
• Wzór empiryczny (zapis Hilla): C₆H₁₅ClN₂O₂
• Numer CAS: 51-83-2
• Masa cząsteczkowa: 182.65
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00012011
• Assay: ≥98% (titration)
• Form: solid (fine crystalline)
• Storage condition: OK to freeze, desiccated (hygroscopic)

Właściwości

• Nazwa produktu: Carbachol, An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors.
• Quality Segment: 100
• description: Merck USA index - 14, 1779
• assay: ≥98% (titration)
• form: solid (fine crystalline)
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: white
• solubility: methanol: 100 mg/mL, water: 100 mg/mL, ethanol: 20 mg/mL
• storage temp.: 10-30°C
• SMILES string: Cl.[N+](CCO\C(=N\[H])\[O-])(C)(C)C
• InChI: 1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H
• InChI key: AIXAANGOTKPUOY-UHFFFAOYSA-N

Opis

General description

An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. Known to increase cytosolic Ca²⁺ and InsP₃ and decrease cAMP levels. Resistant to the action of acetylcholine esterase (AChE) and non-specific cholinesterases. Inhibits apoptotic death of cultured granule neurons.

Biochem/physiol Actions

Primary Target
Agonist for nicotinic and muscarinic acetylcholine receptors

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Other Notes

Jence, M., et al. 1995. J. Neurochem. 64, 1605.
Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248.
Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem.267, 5847.
Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82.
Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther.239, 574.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic (H)

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Informacja o środkach bezpieczeństwa

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Klasa składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable