19-135
Inhibitor p38/SAPK2 (SB 203580)
The p38/SAPK2 Inhibitor (SB 203580) controls the biological activity of p38/SAPK2. This small molecule/inhibitor is primarily used for Biochemicals applications.
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 1 mg | Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o. | 1200,00 zł |
Informacje o tej pozycji
UNSPSC Code:
12352200
NACRES:
NA.41
eCl@ss:
32160405
Pomoc techniczna
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Pozwól nam pomócQuality Level
form
solid
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
1 of 1
Ta pozycja | |||
|---|---|---|---|
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| form solid | form solid | form film (Thin) | form liquid |
| shipped in wet ice | shipped in wet ice | shipped in ambient | shipped in wet ice |
| manufacturer/tradename Upstate® | manufacturer/tradename Upstate® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| technique(s) activity assay: suitable (kinase) | technique(s) activity assay: suitable (kinase) | technique(s) - | technique(s) - |
| NCBI accession no. | NCBI accession no. | NCBI accession no. - | NCBI accession no. - |
Application
Highly specific inhibitor of p38/SAPK2
Biochem/physiol Actions
Inhibitor Type: Kinase
Protein Target: p38/SAPK2
Target Sub-Family: CMGC
Physical form
C12H16FN3OS
Preparation Note
3 years at -20°C
Analysis Note
Routinely evaluated in a kinase assay.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Klasa składowania
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient.
Hazzalin, C A, et al.
Current Biology, 6, 1028-1031 (1996)
Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.
Badger, A M, et al.
Journal of Pharmacology and Experimental Therapeutics, 279, 1453-1461 (1996)
R M Kramer et al.
The Journal of biological chemistry, 271(44), 27723-27729 (1996-11-01)
The Ca2+-sensitive 85-kDa cytosolic phospholipase A2 (cPLA2) is responsible for thrombin-stimulated mobilization of arachidonic acid for the synthesis of thromboxane A2 in human platelets. We have previously shown that thrombin activates p38 kinase, a recently discovered new member of the
J Saklatvala et al.
The Journal of biological chemistry, 271(12), 6586-6589 (1996-03-22)
p38 mitogen-activated protein kinase (MAPK) was identified in platelets on the basis of (a) its reactivity with antibodies to C-terminal and N-terminal peptides, and (b) its ability to activate MAPK-activated protein kinase-2, which phosphorylates the small heat shock protein, hsp27.
Liangxuan Zhang et al.
Infection and immunity, 72(1), 38-45 (2003-12-23)
Our previous studies showed that bacterial heat shock protein 60 (hsp60) induces cultured epithelial cell proliferation within 24 h. Here we investigated the long-term effects of heat shock protein 60 isolated from Actinobacillus actinomycetemcomitans on skin keratinocyte (HaCaT cell line)
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| 19-135 | 04053252285349 |
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