189513

Inhibitor autotaksyny IV, HA155

The Autotaxin Inhibitor IV, HA155 controls the biological activity of Autotaxin. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonim(y): Inhibitor Atx IV, HA155, kwas ( Z)-4-((4-((3-(4-fluorobenzylo)-2,4-diokso-1,3-tiazolan-5-yliden)-metylo)fenoksy)metylo)benzenoboronowy, Inhibitor Atx IV, HA155, kwas(Z)-4-((4-((3-(4-fluorobenzylo)-2,4-diokso-1,3-tiazolan-5-yliden)-metylo)fenoksy)metylo)benzenoboronowy
• Wzór empiryczny (zapis Hilla): C₂₄H₁₉BFNO₅S
• Numer CAS: 1312201-00-5
• Masa cząsteczkowa: 463.29
• UNSPSC Code: 41121800
• NACRES: NA.28
• MDL number: MFCD28016544
• Assay: ≥99% (HPLC)
• Form: powder
• Quality level: 100
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Właściwości

• Quality Level: 100
• assay: ≥99% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• color: yellow
• solubility: DMSO: 100 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O=C(/C(S1)=C/C2=CC=C(OCC3=CC=C(B(O)O)C=C3)C=C2)N(CC4=CC=C(F)C=C4)C1=O
• InChI key: BRWUZCBSWABPMR-XKZIYDEJSA-N

Opis

General description

A ~5-fold more potent (IC₅₀ = 5.7 nM) para-isomer boronate analog of Autotaxin Inhibitor II, HA130 (Cat. No. 189511) that efficiently blocks thrombin-stimulated lysophosphatidic acid secretion in platelets and in mammalian cells.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Fulkerson, Z., et al. 2011. J. Biol. Chem.286, 34654.
Hausmann, J., et al. 2011. Nat. Struct. Mol. Biol.18, 198.
Albers, H.M.H.G., et al. 2011. J. Med. Chem.54, 4619.
Albers, H.M.H.G., et al. 2010. J. Med. Chem.53, 4958.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable