104551

Inhibitor ACC2, CD-017-0191

The ACC2 Inhibitor, CD-017-0191 controls the biological activity of ACC2. This small molecule/inhibitor is primarily used for Cell Signaling applications.

• Synonim(y): 2-((2-(4-izopropoksyfenylo)-5-metylooksazol-4-ylo)metylotio)oksazolo[4,5-b]pirydyna
• Wzór empiryczny (zapis Hilla): C₂₀H₁₉N₃O₃S
• Masa cząsteczkowa: 381.45
• NACRES: NA.28
• UNSPSC Code: 12352200
• Assay: ≥90% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Właściwości

• Quality Segment: 100
• assay: ≥90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white
• solubility: DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Opis

General description

A cell-permeable and selective inhibitor of human Acetyl-CoA carboxylase 2 (ACC2) (IC₅₀ = 2.8 µM), which does not inhibit human ACC1 at all at concentrations up to 100 µM, in vitro. It is also shown to inhibit the growth of yeast (IC₅₀ = 3.8 µM), in which the native ACC1 gene is replaced with the human ACC2 strain; but not with the human ACC1 strain at concentrations ≤ 100 µM. This compound is not demonstrated to be toxic to human cells in culture at concentrations up to 10 µM.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Marjanovic, J., et al. 2010 Proc. Natl. Acad. Sci.107, 9093.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable