06-315
Przeciwciało anty-KA2/GRIK5 (receptor kainianowy)
Upstate®, from rabbit
Synonim(y):
Anti-EAA2, Anty-GRIK2, Anty-GluK5, Anty-KA2
Wybierz wielkość
| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 200 μg | Sprawdź dostępność w koszyku | 2240,00 zł |
Informacje o tej pozycji
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat, rabbit
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... GRIK5(2901)
General description
Immunogen
Application
Neuroscience
Neurochemia i neurotrofiny
Choroby neurodegeneracyjne
Biochem/physiol Actions
Physical form
Preparation Note
Analysis Note
Legal Information
Disclaimer
1 of 1
Ta pozycja | |||
|---|---|---|---|
| antibody form purified antibody | antibody form purified immunoglobulin | antibody form culture supernatant | antibody form affinity isolated antibody |
| clone polyclonal | clone polyclonal | clone NL904, monoclonal | clone polyclonal |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| species reactivity rat, rabbit | species reactivity mouse, human | species reactivity mouse, rat, human | species reactivity human |
| biological source rabbit | biological source rabbit | biological source rabbit | biological source rabbit |
| Gene Information human ... GRIK5(2901) | Gene Information human ... CSN2(1447) | Gene Information human ... GRIK2(2898) | Gene Information human ... GRIK2(2898) |
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Klasa składowania
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Powiązane treści
Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.