D5294

ジラゼプ 二塩酸塩

powder

• 別名: ASTA C 4898, N,N′-ビス(3-[3,4,5-トリメトキシベンゾイルオキシ]プロピル)ホモピペラジン 二塩酸塩, コルメリアン
• 実験式（ヒル表記法）: C₃₁H₄₄N₂O₁₀ · 2HCl
• CAS番号: 20153-98-4
• 分子量: 677.61
• NACRES: NA.77
• PubChem Substance ID: 24278372
• UNSPSC Code: 12352200
• EC Number: 243-548-8
• MDL number: MFCD00133267
• Form: powder

特性

• form: powder
• Quality Segment: 200
• color: white
• solubility: H₂O: 10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl[H].Cl[H].COc1cc(cc(OC)c1OC)C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2
• InChI: 1S/C31H44N2O10.2ClH/c1-36-24-18-22(19-25(37-2)28(24)40-5)30(34)42-16-8-12-32-10-7-11-33(15-14-32)13-9-17-43-31(35)23-20-26(38-3)29(41-6)27(21-23)39-4;;/h18-21H,7-17H2,1-6H3;2*1H
• InChI key: VILIWRRWAWKXRW-UHFFFAOYSA-N
• Gene Information: human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)

詳細

General description

Dilazep comprises central cyclic diamine and phenyl rings connected via alkyl linkers.

Application

Dilazep dihydrochloride has been used in estrogen receptor (ERα) antagonistic assay. It has also been used as an equilibrative nucleoside transporter inhibitor (ENT 1 and 2) in cancer cell lines.[1]

Biochem/physiol Actions

Dilazep is a equilibrative nucleoside transporter 1 (ENTs) inhibitor. It is an antianginal drug and an effective coronary vasodilator. Dilazep elicits anti-albuminuric effects and is an anti-platelet agent. It is a potent adenosine uptake inhibitor and suppresses effects of ischemia.

安全性情報

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• 保管分類: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves