Z0127

ザテブラジン 塩酸塩

≥98% (HPLC), powder

• 別名: 7,8-ジメトキシ-3-[3-[-N-[2-(3,4ジメトキシフェニル)エチル]-N-メチルアミノ]プロピル]-1,3,4,5-テトラヒドロ-2H-3-ベンゾアゼピン-2-オン 塩酸塩, UL-FS49
• 実験式（ヒル表記法）: C₂₆H₃₇ClN₂O₅
• CAS番号: 91940-87-3
• 分子量: 493.04
• MDL番号: MFCD06798356
• UNSPSCコード: 12352200
• PubChem Substance ID: 24724672
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 保管条件: desiccated
• 色: white
• 溶解性: H₂O: >10 mg/mL
• オーガナイザー: Boehringer Ingelheim
• 保管温度: 2-8°C
• SMILES記法: Cl[H].COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC
• InChI: 1S/C26H36N2O5.ClH/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29;/h7-8,15-17H,6,9-14,18H2,1-5H3;1H
• InChI Key: ZRNKXJHEQKMWCH-UHFFFAOYSA-N

詳細

アプリケーション

Zatebradine hydrochloride has been used:

• as an I_f blocker to study its effects on cardiomyocyte clusters (CMCs)
• as a hyperpolarization-activated and cyclic nucleotide-gated (HCN) channel inhibitor to study its effects on viability of degenerating rod or cone photoreceptors in mice
• as a bradycardiac agent to study its effects on tachycardia and elevated temperature in fish

生物化学的／生理学的作用

Zatebradine is a bradycardiac agent.

HCNチャネルブロッカ-で、I_hニュ-ロンをブロックし、心臓I_fチャネルおよびATP感受性K_irチャネルにも関係しています。

特徴および利点

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)