ABT59
Anti-Pericentrin Antibody
from rabbit, purified by affinity chromatography
Synonim(y):
Pericentrin, Kendrin, Pericentrin-B
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 100 μg | Przewidywana wysyłka DZISIAJzKuehne + Nagel Sp. z o.o. | 1860,00 zł |
Informacje o tej pozycji
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, WB
Citations:
6
1860,00 zł
Przewidywana wysyłka DZISIAJSzczegóły
Rekombinowane, niezawierające konserwantów przeciwciało jest dostępne dla Twojego celu. Wypróbuj ZRB1318
Pomoc techniczna
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Pozwól nam pomócbiological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
technique(s)
immunocytochemistry: suitable, western blot: suitable
NCBI accession no.
General description
Pericentrin binds to calmodulin and is expressed in the centrosome that serves as a multifunctional scaffold for anchoring proteins and protein complexes. Evidence suggests that pericentrin plays a role in microtubule nucleation and spindle organization. Recent studies show pericentrin plays a role in Majewski/micorcephalic osteodysplastic primordial dwarfism type II (MOPDII) and Seckel Syndrome. Recent use in network modeling indicates a direct link between breast cancer susceptibility to centrosome defects. Pericentrin is a potential marker for centrosome defects in cancer and cancer progression, as centrosomal abonormalities in solid tumors are accompanied by increased pericentrin levels and defects in pericentrin organization.
~250 kDa observed.
Uniprot describes 2 isoforms produced by alternative splicing with molecular weights at 378 & 355 kDa However in endogenous lysates, Pericentrin is observed at ~250 kDa & ~150 kDa for western blots (Wen, Y., et al. (2008). J Biol Chem. 283(5):2793-2803).
Uniprot describes 2 isoforms produced by alternative splicing with molecular weights at 378 & 355 kDa However in endogenous lysates, Pericentrin is observed at ~250 kDa & ~150 kDa for western blots (Wen, Y., et al. (2008). J Biol Chem. 283(5):2793-2803).
Immunogen
KLH-conjugated linear peptide corresponding to human Pericentrin.
Application
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Pericentrin in HeLa cells.
This Anti-Pericentrin Antibody is validated for use in WB, IC for the detection of Pericentrin.
Biochem/physiol Actions
Other homologies: Mouse (89% sequence homology). No homology to Rat was found.
Analysis Note
Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Pericentrin in 10 µg of HeLa cell lysate. Western Blot was performed without Tween.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Pericentrin in 10 µg of HeLa cell lysate. Western Blot was performed without Tween.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Klasa składowania
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
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Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| ABT59 | 04053252420634 |
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