444898

Mastoparan

A cell-permeable synthetic peptide with sequence identical to Vespula lewisii.

• Synonim(y): Mastoparan, INLKALAALAKKIL
• Wzór empiryczny (zapis Hilla): C₇₀H₁₃₁N₁₉O₁₅
• Numer CAS: 72093-21-1
• Masa cząsteczkowa: 1478.91
• Numer MDL: MFCD00076865
• Kod UNSPSC: 51111800
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥97% (HPLC)
• Postać: solid
• siła działania: 7.5 μM IC₅₀
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze
• kolor: white
• rozpuszczalność: water: 5 mg/mL
• Warunki transportu: ambient
• temp. przechowywania: −20°C
• InChI: 1S/C70H131N19O15/c1-17-40(11)55(75)69(103)88-53(35-54(74)90)68(102)87-52(34-39(9)10)67(101)83-46(25-19-22-28-71)62(96)78-45(16)61(95)86-50(32-37(5)6)65(99)79-42(13)58(92)77-43(14)60(94)85-51(33-38(7)8)66(100)80-44(15)59(93)81-47(26-20-23-29-72)63(97)82-48(27-21-24-30-73)64(98)89-56(41(12)18-2)70(104)84-49(57(76)91)31-36(3)4/h36-53,55-56H,17-35,71-73,75H2,1-16H3,(H2,74,90)(H2,76,91)(H,77,92)(H,78,96)(H,79,99)(H,80,100)(H,81,93)(H,82,97)(H,83,101)(H,84,104)(H,85,94)(H,86,95)(H,87,102)(H,88,103)(H,89,98)/t40-,41?,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,55-,56-/m0/s1
• Klucz InChI: MASXKPLGZRMBJF-HDSAQESISA-N

Opis

Opis ogólny

A cell-permeable synthetic peptide with a sequence identical to Vespula lewisii. Amphiphilic wasp venom tetradecapeptide capable of directly activating pertussis toxin-sensitive G-proteins by a mechanism analogous to that of G-protein-coupled receptors. Acts preferentially on G_i and G_o rather than G_s. Potent factor in mitochondrial permeability transition pore. Inhibits calmodulin and activates phospholipase A₂. Causes a transient Ca²⁺ release from the sarcoplasmic reticulum.

A cell-permeable synthetic peptide with sequence identical to Vespula lewisii. Amphiphilic wasp venom tetradecapeptide capable of directly activating pertussis toxin-sensitive G-proteins by a mechanism analogous to that of G-protein-coupled receptors. Acts preferentially on G_i and G_o rather than G_s. Potent facilitator of the mitochondrial permeability transition pore that is reported to induce apoptosis in cultured cerebellar granule neurons by causing a dramatic increase in intracellular Ca²⁺. Acts as a calmodulin antagonist and activates phospholipase A₂. Causes a transient Ca²⁺ release from the sarcoplasmic reticulum. Also reported to inhibit Na⁺,K⁺-ATPase activity (IC₅₀ = 7.5 µM).

Działania biochem./fizjol.

Cell permeable: yes

Primary Target
Na⁺,K⁺-ATPase activity

Product does not compete with ATP.

Reversible: no

Opakowanie

Yes

Ostrzeżenie

Toxicity: Standard Handling (A)

Sekwencja

H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH₂

Postać fizyczna

Supplied as a trifluoroacetate salt.

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Inne uwagi

Hirata, Y., et al. 2000. Mol. Pharmacol. 57, 1235.
Liz, S.Z., et al. 1997. Brain Res.771, 184.
Klinker, J.F., et al. 1996. Biochem. Pharmacol. 51, 217.
Langel, U., et al. 1996. Regul. Peptides 62, 47.
Pfeiffer, D.R., et al. 1995. J. Biol. Chem. 270, 4923.
Igarashi, M., et al. 1993. Science259, 77.
Komatsu, M., et al. 1992. Endocrinology130, 221.
Adolfo Garcia-Sainz, J., et al. 1991. Biochem. Biophys. Res. Commun.179, 852.
Gil, J., et al. 1991. J. Cell Biol. 113, 943.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable