D134

3,7-ジメチル-1-プロパルギルキサンチン

≥98% (HPLC), powder

• 別名: 3,7-ジメチル-1-(2-プロピニル)キサンチン, DMPX
• 実験式（ヒル表記法）: C₁₀H₁₀N₄O₂
• CAS番号: 14114-46-6
• 分子量: 218.21
• NACRES: NA.77
• PubChem Substance ID: 24277754
• UNSPSC Code: 12352200
• MDL number: MFCD00078576
• Assay: ≥98% (HPLC)
• Form: powder

特性

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 15 mg/mL, clear
• SMILES string: CN1C(=O)N(CC#C)C(=O)c2c1ncn2C
• InChI: 1S/C10H10N4O2/c1-4-5-14-9(15)7-8(11-6-12(7)2)13(3)10(14)16/h1,6H,5H2,2-3H3
• InChI key: IORPOFJLSIHJOG-UHFFFAOYSA-N
• Gene Information: human ... ADORA2A(135), ADORA2B(136) ; rat ... Adora1(29290), Adora2a(25369)

詳細

Application

3,7-Dimethyl-1-propargylxanthine (DMPX) has been used as an A₂ -adenosine receptor (AR) antagonist:

• to study its effects on potential modulation of motor output elicited by epidural spinal stimulation (ESS)[1]
• to study the role of A_2a receptor in elevating cyclic adenosine monophosphate (cAMP) levels[2]
• to study its effects on the cell viability of human gastric cancer cell line[3]

Biochem/physiol Actions

3,7-Dimethyl-1-propargylxanthine (DMPX) is a caffeine analog and A₂-selective adenosine receptor (AR) antagonist.[4][5]

安全性情報

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• 保管分類: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves