A4847
アルスターパウロン
≥98% (HPLC), GSK-3β and CDK5/p25 inhibitor, powder
別名:
9-ニトロ-7,12-ジヒドロインドロ-[3,2-d][1]ベンゾアゼピン-6(5)-オン
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| あなたへ/カタログ番号 | 在庫状況 | 単価 |
|---|---|---|
1 mg | カートの在庫状況を確認する | ￥29,800 |
この商品について
実験式（ヒル表記法）:
C16H11N3O3
CAS番号:
分子量:
293.28
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
製品名
アルスターパウロン, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
yellow to brown
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
SMILES string
[O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
InChI
1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
InChI key
OLUKILHGKRVDCT-UHFFFAOYSA-N
Gene Information
rat ... Gsk3b(84027)
Application
Alsterpaullone inhibits GSK-3β, CDK5/p25, and CDK1/cyclin B. Alsterpaullone has also been studied as an antimanic therapeutic for the acute manic phase of bipolar disorder.
Alsterpaullone has been used to stabilize β-catenin.
Biochem/physiol Actions
GSK-3βおよびCDK5/p25の強力かつ選択的なインヒビタ-です。また、CDK1/サイクリンBの強力なインヒビタ-です(IC50= 0.035μM)。
Alsterpaullone (ALP) is a cyclin-dependent kinase (CDK) inhibitor. It is considered as a therapeutic agent for group 3 medulloblastomas. Alsterpaullone modulates the progression of cell cycle. It can arrest cell cycle and stimulate the apoptosis of cancer cells by activating caspase-9 through perturbation of mitochondrial membrane potential.
Features and Benefits
This compound is featured on the CDKs and GSK-3 pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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当該品目 | |||
|---|---|---|---|
| form powder | form solid | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| storage condition desiccated | storage condition OK to freeze, protect from light | storage condition - | storage condition - |
| solubility DMSO: ≥10 mg/mL | solubility DMSO: 20 mg/mL | solubility DMSO: 15 mg/mL, clear | solubility DMSO: 10 mg/mL, clear |
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保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves