ABS403

Anti-phospho NFkB p65 Antibody, (Ser547)

from rabbit, purified by affinity chromatography

• 別名: Transcription factor p65, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: human
• 化学種の反応性（ホモロジーによる予測）: chimpanzee (based on 100% sequence homology), bovine (based on 100% sequence homology), rat (based on 100% sequence homology), mouse (based on 100% sequence homology), porcine (based on 100% sequence homology)
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_068810
• UniProtアクセッション番号: Q04206
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: phosphorylation (pSer547)
• 遺伝子情報: human ... RELA(5970)

詳細

詳細

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa B forms multiple homo and heterodimeric complexes, one of which is with RELA/p65. The NF-kappa-B p65 complex appears to be involved in invasin-mediated activation of IL-8 expression, as well as the inhibitor effect on I-kappa-B. Phosphorylation of p65 at serine 547 by the nuclear kinase ATM appears to repress NF-κB-dependent transcription of specific genes induced by genotoxic stress.

免疫原

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to the C-terminus of human phospho NFkB p65, (Ser547).

アプリケーション

Research Category
細胞シグナル伝達

Research Sub Category
神経シグナリング

Anti-phospho NFkB p65 Antibody, (Ser547) is an antibody against phospho NFkB p65 Antibody for use in Western Blotting.

品質

Evaluated by Western Blotting in p65 WT transfected U2OS cell lysate.

Western Blotting Analysis: A 1:5,000 dilution of this antibody detected phospho NFkB p65, (Ser547) in 10 µg of p65 WT transfected U2OS cell lysate.

ターゲットの説明

~62 kDa observed. Uncharacterized band(s) may appear in some lysates.

物理的形状

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable