8.52007

Fmoc-Cys(tBu)-OH

Novabiochem^®

• 別名: Fmoc-Cys(tBu)-OH, N-α-Fmoc-S-t.-butyl-L-cysteine
• 実験式（ヒル表記法）: C₂₂H₂₅NO₄S
• CAS番号: 67436-13-9
• 分子量: 399.50
• MDL番号: MFCD00037130
• UNSPSCコード: 12352209
• NACRES: NA.22

特性

• 品質水準: 200
• 製品種目: Novabiochem^®
• アッセイ: ≥97.0% (acidimetric); ≥98% (TLC); ≥98.0% (HPLC)
• 形状: powder
• 反応適合性: reaction type: Fmoc solid-phase peptide synthesis
• メーカー／製品名: Novabiochem^®
• mp: 133-136 °C
• アプリケーション: peptide synthesis
• 官能基: thiol
• 保管温度: 2-30°C
• InChI: 1S/C22H25NO4S/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)
• InChI Key: IXAYZHCPEYTWHW-UHFFFAOYSA-N

詳細

詳細

The side-chain tBu group is stable to TFA and iodine oxidation. Treatment with MeSiCl₃/PhSOPh removes t-Bu and cyclizes in one step without scrambling existing disulphide bonds. Removed with Hg(II) to give cysteinyl peptides.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides

Literature references

^[1] S. N. McCurdy (1989) Pept. Res., 2, 147.

関連事項

Replaces: 04-12-1016

アナリシスノート

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 97.0 %
Water (K. F.): ≤ 1.00 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法的情報

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable