The highest test point found is that the substance is soluble in DMSO at a concentration of 50 mg/ml.
481981
Nifedipine
≥98% (UV), L-type Ca2+ channel bocker, solid
別名:
Nifedipine, L-Type Calcium Channel Blocker III
ログインで組織・契約価格をご覧ください。
サイズを選択してください
表示を変更する
| 容量 | カタログ番号 | 在庫状況 | 単価 |
|---|
この商品について
実験式（ヒル表記法）:
C17H18N2O6
CAS番号:
分子量:
346.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
この製品は、Merck Milliporeウェブサイトでのみ注文できます。
製品名
Nifedipine, Relatively selective blocker of L-type Ca2+ channels.
description
Merck USA index - 14, 6528
Quality Level
assay
≥98% (UV)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: soluble, ethanol: soluble
shipped in
ambient
storage temp.
10-30°C
SMILES string
[N+](=O)([O-])c1c(cccc1)C2C(=C(NC(=C2C(=O)OC)C)C)C(=O)OC
InChI
1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
InChI key
HYIMSNHJOBLJNT-UHFFFAOYSA-N
General description
Relatively selective blocker of L-type Ca2+ channels. One of the most extensively studied blockers of 1,4-dihydropyridine-type Ca2+ channels, and a pharmacologically-useful vasodilator. Induces apoptosis in human glioblastoma cells.
Biochem/physiol Actions
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
L-type Ca2+ channels
L-type Ca2+ channels
Preparation Note
Following reconstitution, refrigerate (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Reid, K., et al. 1997. J. Pharmacol. Exp. Ther. 283, 993.
Kondo, S., et al. 1995. J. Neurosurg.82, 469.
Antkiewicz-Michaluk, L., et al. 1994. Eur. J. Pharmacol. 254, 9.
Calabresi, P., et al. 1994. J. Neurosci. 14, 4871.
Akman, M.S., et al. 1993. Endocrinology132, 1286.
Cirillo, M., et al. 1993. Circ. Res.72, 847.
Young, R.J., et al. 1993. Biochim. Biophys. Acta1146, 81.
Janis, R., et al. 1987. Adv. Drug Res.16, 311.
Kondo, S., et al. 1995. J. Neurosurg.82, 469.
Antkiewicz-Michaluk, L., et al. 1994. Eur. J. Pharmacol. 254, 9.
Calabresi, P., et al. 1994. J. Neurosci. 14, 4871.
Akman, M.S., et al. 1993. Endocrinology132, 1286.
Cirillo, M., et al. 1993. Circ. Res.72, 847.
Young, R.J., et al. 1993. Biochim. Biophys. Acta1146, 81.
Janis, R., et al. 1987. Adv. Drug Res.16, 311.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
1 of 1
当該品目 | |||
|---|---|---|---|
| assay ≥98% (UV) | assay - | assay - | assay - |
| form solid | form - | form - | form solid |
| manufacturer/tradename Calbiochem® | manufacturer/tradename EDQM | manufacturer/tradename - | manufacturer/tradename BP |
| Quality Level 100 | Quality Level - | Quality Level 300 | Quality Level - |
| storage temp. 10-30°C | storage temp. - | storage temp. 2-30°C | storage temp. 2-8°C |
| storage condition OK to freeze, protect from light | storage condition - | storage condition - | storage condition - |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
481981-MG: + 481981-250MG: + 481981-1.1ML:
jan
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Mehmet Şerif Aydın et al.
iScience, 26(10), 107715-107715 (2023-09-13)
Trauma, vascular events, or neurodegenerative processes can lead to axonal injury and eventual transection (axotomy). Neurons can survive axotomy, yet the underlying mechanisms are not fully understood. Excessive water entry into injured neurons poses a particular risk due to swelling
Nubia Carolina Manchola Varón et al.
Frontiers in cellular and infection microbiology, 11, 731372-731372 (2021-10-22)
Trypanosoma cruzi, the etiological agent of Chagas disease in humans, infects a wide variety of vertebrates. Trypomastigotes, the parasite infective forms, invade mammalian cells by a still poorly understood mechanism. Adhesion of tissue culture- derived trypomastigotes to the extracellular matrix
Mark R Davies et al.
Cell reports. Medicine, 1(5), 100076-100076 (2020-11-19)
There is an increasing expectation that computational approaches may supplement existing human decision-making. Frontloading of models for cardiac safety prediction is no exception to this trend, and ongoing regulatory initiatives propose use of high-throughput in vitro data combined with computational models
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 481981-250MG | 04055977183443 |