F7680
FAK(393-698)、活性型、Hisタグ融合 ヒト
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
別名:
FADK, FAK1, PTK2, pp125FAK
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この商品について
NACRES:
NA.32
UNSPSC Code:
12352204
Specific activity:
221-299 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells
recombinant
expressed in baculovirus infected Sf9 cells
Quality Segment
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
221-299 nmol/min·mg
mol wt
~35 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PTK2(5747)
General description
Focal adhesion kinase (FAK) or PTK2 (protein tyrosine kinase 2) is a tyrosine kinase, which resides in the cytoplasm, and concentrated at cellular focal points. It is a highly conserved 125kDa protein, which has a wide range of tissue expression. It is composed of 1,052 amino acids, and contains N- and C-termini flanking the central kinase domain. The N-terminal called the FERM (four-point-one, ezrin, radixin, moesin) domain, controls FAK activity, whereas the C-terminal contains the focal-adhesion-targeting (FAT) domain.[1]
Biochem/physiol Actions
Focal adhesion kinase (FAK) or PTK2 protein tyrosine kinase 2 plays multiple roles such as, control of transcription, cell cycle progression, apoptosis, cell migration, and metastasis in case of tumor cells. This attributes to its predominant role in cell signaling. It is involved in the infection of rabies virus (RABV).[1] Studies in Spanish population show that polymorphisms rs7460 and rs7843014 in this gene might be linked with exceptional longevity.[2] Phosphatidylinositol 4-phosphate 5-kinase type Iγ enzyme produces phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] in focal adhesion, which cross-links FAK activation to integrin signaling.[3]
Physical form
50 mMリン酸ナトリウムバッファー(pH 7.0、300 mM NaCl、150 mMイミダゾール、0.1 mM PMSF、0.2 mM DTT、25%グリセロール含有)で提供されます。
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
F7680-VAR: + F7680-10UG-PW: + F7680-10UG: + F7680-BULK:
jan