E9531

エバスチン

≥98% (HPLC), Histamine H1 receptor antagonist, solid

• 別名: 1-[4-(1,1-ジメチルエチル)フェニル]-4-[4-(ジフェニルメトキシ)-1-ピペリジニル]-1-ブタノン
• 実験式（ヒル表記法）: C₃₂H₃₉NO₂
• CAS番号: 90729-43-4
• 分子量: 469.66
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799086
• NACRES: NA.77
• MDL number: MFCD00865661
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100

特性

• 製品名: エバスチン, ≥98% (HPLC), solid
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: >10 mg/mL, H₂O: insoluble
• storage temp.: room temp
• SMILES string: CC(C)(C)c1ccc(cc1)C(=O)CCCN2CCC(CC2)OC(c3ccccc3)c4ccccc4
• InChI: 1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
• InChI key: MJJALKDDGIKVBE-UHFFFAOYSA-N

詳細

General description

Ebastine is metabolised by cytochrome P450 3A (CYP3A4) to carebastine. It is used to treat allergic rhinitis and chronic idiopathic urticaria.

Application

Ebastine has been used as a cationic amphiphilic drug (CAD) in sensitizing cancerous cells to chemotherapy and revert multidrug resistance.

Biochem/physiol Actions

Ebastine is a non-sedating histamine H₁ receptor antagonist, which inhibits allergen-induced bronchospasm in conscious guinea pigs. Unlike other compounds in this category, ebastine does not prolong the QT interval at up to five times the recommended therapeutic dose.

Ebastine is a non-sedating histamine H₁ receptor antagonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)