由来生物
mouse
結合体
unconjugated
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
EEA1-C33, monoclonal
フォーム
buffered aqueous solution
分子量
antigen ~160 kDa
交差性
human, mouse, rat
濃度
~1.0 mg/mL
テクニック
western blot: 2-4 μg/mL using whole extract of rat NRK or human HeLa cells
アイソタイプ
IgG1
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... EEA1(8411)
mouse ... Eea1(216238)
rat ... Eea1(314764)
詳細
The gene Early Endosome Antigen 1 (EEA1) encodes for around 1400 amino acid proteins. It is a peripheral membrane protein associated with the cytoplasmic face of early endosomes. EEA1 is a autoantigen associated with subacute cutaneous systemic lupus erythematosus and is a coiled-coil protein localized to early endosomes and cytosol.
アプリケーション
Monoclonal Anti-EEA1 antibody produced in mouse is suitable for the following applications:
- Western blotting (at a concentration of 2-4μg/mL using whole extract of rat NRK or human HeLa cells)
- Immunofluorescence Analysis
- Immunocytochemistry
生物化学的／生理学的作用
Early Endosome Antigen 1 (EEA1) controls vesicle fusion during endocytosis. In neurons, it is involved in recycling of synaptic vesicles and neurotransmitter receptors. Patients with neurological deficits develop EEA1 autoantibodies. Mutation in EEA1 gene leads to susceptibility to diabetes in the Japanese population. Phosphatidylinositol 3-phosphate (PtdIns(3)P) is essential for the localization and function of EEA1.
物理的形状
0.01M PBS溶液(pH 7.4, 15 mMアジ化ナトリウム含有)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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