A6469

アペリン-13 トリフルオロアセタート塩

≥95%, APJ receptor agonist, powder

• 別名: プレプロ-65-77-アペリン
• 実験式（ヒル表記法）: C₆₉H₁₁₁N₂₃O₁₆S · C₂F₃O₂
• 分子量: 1663.84
• UNSPSC Code: 12352202
• PubChem Substance ID: 329770894
• NACRES: NA.32
• Assay: ≥95%
• Form: powder

特性

• 製品名: アペリン-13 トリフルオロアセタート塩, ≥95%
• Quality Segment: 200
• assay: ≥95%
• form: powder
• UniProt accession no.: Q9ULZ1
• storage temp.: −20°C
• SMILES string: OC(=O)C(F)(F)F.CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N4CCC[C@H]4C(=O)N[C@@H](Cc5ccccc5)C(O)=O
• InChI: 1S/C69H111N23O16S.C2HF3O2/c1-39(2)32-47(86-58(98)44(17-9-26-78-68(73)74)83-63(103)52-20-12-29-91(52)65(105)45(18-10-27-79-69(75)76)84-56(96)42(71)22-23-54(72)94)59(99)89-50(37-93)61(101)87-48(34-41-35-77-38-81-41)60(100)82-43(16-7-8-25-70)57(97)80-36-55(95)90-28-11-19-51(90)62(102)85-46(24-31-109-3)66(106)92-30-13-21-53(92)64(104)88-49(67(107)108)33-40-14-5-4-6-15-40;3-2(4,5)1(6)7/h4-6,14-15,35,38-39,42-53,93H,7-13,16-34,36-37,70-71H2,1-3H3,(H2,72,94)(H,77,81)(H,80,97)(H,82,100)(H,83,103)(H,84,96)(H,85,102)(H,86,98)(H,87,101)(H,88,104)(H,89,99)(H,107,108)(H4,73,74,78)(H4,75,76,79);(H,6,7)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-;/m0./s1
• InChI key: IUOVYCLNUOUEHV-PDGAQFIRSA-N
• Gene Information: human ... APLN(8862)

詳細

General description

Apelin is a regulatory peptide and a ligand of the APJ receptor. It is a member of the G protein-coupled receptor family. Apelin and APJ are broadly dispersed in the body.

Application

Apelin-13 trifluoroacetate salt has been used to determine whether apelin promotes progression of diabetic nephropathy (DN) by inducing podocyte dysfunction. It has also been used to examine the effects of apelin on myocardial infarction (MI) injury and underlying mechanisms.

Biochem/physiol Actions

ヒトAPJレセプタ-に対する内在性ペプチドアゴニストの合成品であり、 APJレセプタ-はアンジオテンシンレセプタ-(AT₁)と類縁のレセプタ-タンパク質であると推定されています。APJレセプタ-を発現するCHO細胞において、酸性化比率を促進する活性を発揮し、その半有効濃度(EC₅₀)は0.37 nMです。APJレセプタ-を発現する細胞へのHIV-1およびHIV-2の侵入を阻止します。

Apelin plays physiological roles in the cytoprotection of many internal organs. It is used to treat insulin resistance and hypertension, but it may also can act as a negative factor. Apelin also regulates cardiovascular diseases.

Other Notes

Lyophilized from 0.1% TFA in H2O

安全性情報

• 保管分類: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)