Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
A0580
アラキドニルエタノールアミド
≥97.0% (TLC), oil
別名:
アナンダミド(20:4, n-6), AEA, アナンダミド, アラキドン酸 N-(ヒドロキシメチル)アミド
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| 容量 | カタログ番号 | 在庫状況 | 単価 |
|---|---|---|---|
| 5 mg | カートの在庫状況を確認する | ￥21,900 | |
| 25 mg | カートの在庫状況を確認する | ￥61,900 |
この商品について
実験式（ヒル表記法）:
C22H37NO2
CAS番号:
分子量:
347.53
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
Quality Level
assay
≥97.0% (TLC)
form
oil
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
color
colorless to light yellow
solubility
ethanol: soluble
density
0.92 g/mL at 25 °C (lit.)
lipid type
omega FAs
shipped in
dry ice
storage temp.
−20°C
SMILES string
O=C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)NCCO
InChI
1S/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h6-7,9-10,12-13,15-16,24H,2-5,8,11,14,17-21H2,1H3,(H,23,25)/b7-6-,10-9-,13-12-,16-15-
InChI key
LGEQQWMQCRIYKG-DOFZRALJSA-N
Gene Information
rat ... Cnr1(25248)
Application
- 内因性カンナビノイド系と内在性オピオイド系間の相互作用が、帝王切開術を受ける妊婦の術後オピオイド使用に影響を与える可能性：アラキドニルエタノールアミドとオピオイド系との相互作用を調査し、術後疼痛とオピオイド使用の管理改善に役立つ知見を提供しています（Stone et al., 2024）。
Biochem/physiol Actions
CBカンナビノイド受容体およびVR1バニロイド受容体の内因性リガンドであるアラキドン酸誘導体。神経芽細胞腫とニューロンにおいてカルシウム電流を抑制します。MAPキナーゼシグナル伝達経路を活性化します。リンパ球およびヒト乳がん細胞の増殖を抑制し、アポトーシスを誘導します。
Disclaimer
光と湿気を避けて保存してください。
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当該品目 | |||
|---|---|---|---|
| assay ≥97.0% (TLC) | assay ≥99% (TLC and GC) | assay ~98% (TLC) | assay >99% (TLC) |
| form oil | form oil | form powder | form liquid |
| storage temp. −20°C | storage temp. −70°C | storage temp. −20°C | storage temp. −70°C |
| solubility ethanol: soluble | solubility ethanol: 5 mg/mL | solubility chloroform: 20 mg/mL, clear, colorless | solubility - |
| shipped in dry ice | shipped in dry ice | shipped in - | shipped in dry ice |
| density 0.92 g/mL at 25 °C (lit.) | density - | density - | density - |
保管分類
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Cristina Miralpeix et al.
Journal of lipid research, 60(7), 1260-1269 (2019-05-30)
The endocannabinoid (eCB) system regulates energy homeostasis and is linked to obesity development. However, the exact dynamic and regulation of eCBs in the hypothalamus during obesity progression remain incompletely described and understood. Our study examined the time course of responses
Weiwei Dong et al.
PloS one, 9(6), e100436-e100436 (2014-06-21)
Swanson's literature-based discovery focus on resurrecting previously published but neglected knowledge. In this study, we propose a two-step model of the discovery process and generate a hypothesis between anandamide and gastric cancer. Further, the potential relationship was confirmed by follow-up
Bala Attili et al.
British journal of pharmacology, 176(10), 1481-1491 (2018-12-28)
Non-invasive in vivo imaging of cannabinoid CB2 receptors using PET is pursued to study neuroinflammation. The purpose of this study is to evaluate the in vivo binding specificity of [18 F]MA3, a CB2 receptor agonist, in a rat model with
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| A0580-5MG | 04061833334133 |
| A0580-25MG | 04061833334126 |
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What is the Department of Transportation shipping information for this product?
1 回答-
役に立ちましたか？
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How to dissolve Product A0580, Arachidonylethanolamide?
1 回答-
Arachidonylethanolamide (also known as anandamide) is soluble in ethanol (100 mM) and in DMSO (10 mg/ml) and is poorly soluble in water. Hydroxypropyl -β cyclodextran has been reported to increase the aqueous solubility and stability of anandamide. Jarho, P. et al., Life Sciences, 58, 181 (1996).
役に立ちましたか？
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Is Product A0580, Arachidonylethanolamide, a solution?
1 回答-
No, the product is naturally an oily liquid. An approximate molarity for the liquid is 2.6 M (based on a molecular weight of 347.5 g/mole and an approximate density of 0.92 g/mL at 25°C).
役に立ちましたか？
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Can solutions of Product A0580, Arachidonylethanolamide, be stored?
1 回答-
Sigma has not evaluated the solution stability of this product. Solutions in ethanol, stored under argon at -20°C, have been reported (see Schuel, H.. et al., Proc. Nat. Acad. Sci., USA, 91, 7678-7682 (1994) and Spivak, C.E., Mol. Pharmacol., 72, 1024-1032 (2007)). If solutions are to be stored, it would be best to use a degassed solvent or solvent purged with argon. Store solutions under argon in the freezer, at -20°C or colder. Store solutions protected from light and oxygen to prevent the oxidation of the double bonds.
役に立ちましたか？
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