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PC154

Anti-Excitatory Amino Acid Transporter (GLT-1) Rabbit pAb

Name: Anti-Excitatory Amino Acid Transporter (GLT-1) Rabbit pAb
Brand: MM

liquid, Calbiochem^®

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容量	カタログ番号	在庫状況	単価

この商品について

NACRES:

NA.43

UNSPSC Code:

12352203

Clone:

polyclonal

Species reactivity:

rat

Application:

—

Citations:

この製品は、Merck Milliporeウェブサイトでのみ注文できます。

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特性

biological source

rabbit

Quality Level

100

antibody form

diluted serum

antibody product type

primary antibodies

clone

polyclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity

rat

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

dilution

(Immunoblotting (1:1000)
Immunoprecipitation )

isotype

IgG

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

Rattus norvegicus ... Slc1A2(29482)

詳細

General description

Anti-Excitatory Amino Acid Transporter (GLT-1), rabbit polyclonal recognizes the ~75 kDa and the ~50 kDa forms of GLT-1. It is validated for use in Western blotting and immunoprecipitation.

Rabbit polyclonal antibody supplied as diluted serum. Recognizes the ~75 kDa and the ~50 kDa forms of GLT-1.

Recognizes the ~75 kDa and the ~50 kDa forms of GLT-1.

Immunogen

a synthetic peptide (NGKSADCSVEEEPWKREK) corresponding to amino acids at the C-terminus of rat GLT-1

Application

Immunoblotting (1:1000)Immunoprecipitation

Other Notes

Arriza, J.L., et al. 1997. Proc. Natl. Acad. Sci. USA94, 4155.
Nagao, S., et al. 1997. Neuroscience78, 929.
Rothstein, J.D., et al. 1995. Ann. Neurol.14, 5559.
Arriza, J.L., et al. 1994. J. Neurosci.14, 5559.
Rothstein, J.D., et al. 1993. Proc. Natl. Acad. Sci. USA90, 6591.
Kanai, Y., et al. 1992. Nature360, 467.
Pines, G., et al. 1992. Nature360, 464.
Rothstein, J.D., et al. 1992. N. Engl J. Med.326, 1464.
Storck T., et al. 1992. Proc. Natl. Acad. Sci. USA89, 10955.

This antibody may also cross react nonspecifically with a ~102 kDa protein not believed to be related to GLT-1. This antibody has also been reported to work for immunoprecipitation. Antibody should be titrated for optimal results in individual systems.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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当該品目	178467	354206	400061
Sigma-Aldrich PC154 Anti-Excitatory Amino Acid Transporter (GLT-1) Rabbit pAb	Sigma-Aldrich 178467 Anti-Apolipoprotein B Goat pAb	Sigma-Aldrich 354206 Anti-Glutathione S-Transferase A1-1 Rabbit pAb	Sigma-Aldrich 400061 Anti-Glucose Transporter-2 Rabbit pAb
biological source rabbit	biological source goat	biological source rabbit	biological source rabbit
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
antibody form diluted serum	antibody form diluted serum	antibody form serum	antibody form affinity isolated antibody
shipped in wet ice	shipped in wet ice	shipped in wet ice	shipped in wet ice
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal
Gene Information Rattus norvegicus ... Slc1A2(29482)	Gene Information -	Gene Information human ... GSTA1(2938)	Gene Information human ... SLC2A2(6514)

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保管分類

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

PC154-100UL: + PC154-UL: + US1PC154-EACH:

jan

試験成績書（COA）

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以前この製品を購入いただいたことがある場合

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Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.

Inhibition of glutamate/glutamine cycle in vivo results in decreased benzodiazepine binding and differentially regulated GABAergic subunit expression in the rat brain.

Christian M Cremer et al.

Epilepsia, 51(8), 1446-1455 (2010-04-14)

The astrocytic enzyme glutamine synthetase (GS) is a key regulator of glutamate and γ-aminobutyric acid (GABA) metabolism in the glutamate/glutamine cycle (GGC). Inhibition of GS results in changes of neurotransmitter release and recycling. However, little is known about the influence

グローバルトレードアイテム番号

カタログ番号	GTIN
PC154-100UL	04055977209488

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