382425

Trequinsin, Hydrochloride

Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC₅₀ = 300 pM) and platelet aggregation in vitro.

• 別名: Trequinsin, Hydrochloride, 9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725
• 実験式（ヒル表記法）: C₂₄H₂₇N₃O₃ · xHCl
• CAS番号: 78416-81-6
• 分子量: 405.49 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD01076563
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, desiccated

特性

• Quality Level: 100
• description: RTECS - UW7727000
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: pale yellow
• solubility: water: 500 μM
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: Cl.[n]21c(c[c]([n]([c]2=O)C)=Nc4c(cc(cc4C)C)C)c3c(cc(c(c3)OC)OC)CC1
• InChI: 1S/C24H27N3O3.ClH/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4;/h9-13H,7-8H2,1-6H3;1H
• InChI key: DTCZZBVPTHVXFA-UHFFFAOYSA-N

詳細

General description

Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC₅₀ = 300 pM) and platelet aggregation in vitro. Potentiates adenosine-stimulated cAMP accumulation.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
cGMP-inhibited phosphodiesterase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 300 pM against cGMP-inhibited phosphodiesterase

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Spina, D., et al. 1998. Life Sci. 62, 953.
Pillai, R., et al. 1994. J. Biol. Chem.269, 30676.
Tang, K.M., et al. 1994. Eur. J. Pharmacol.268, 105.
Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci.11, 150.
DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
Ruppert, D., and Weithmann, K.U. 1982. Life Sci.31, 2037.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

安全性情報

• 保管分類: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable