The solubility and solution stability of this product have not been determined. However, online sources report that this material is soluble in DMSO and Ethanol at >50 mg/mL. Anhydrous solvents are recommended. Stock solutions may be stored up to 1 month at -20°C for 1 year at -80°C. This information has not been validated.
C6492
Ciproxifan hydrochloride
≥98% (HPLC), solid
Sinonimo/i:
Cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxyl]phenyl]-methanone hydrochloride
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Cambia visualizzazione
| Taglio della confezione | SKU | Disponibilità | Prezzo |
|---|---|---|---|
| 5 mg | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 214,00 € | |
| 25 mg | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 533,00 € |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C16H18N2O2 · HCl
Numero CAS:
Peso molecolare:
306.79
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
214,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Servizio Tecnico
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Permettici di aiutartiQuality Level
assay
≥98% (HPLC)
form
solid
storage condition
desiccated, under inert gas
color
off-white
solubility
DMSO: 30 mg/mL, water, high purity: 30 mg/mL
storage temp.
2-8°C
SMILES string
Cl.O=C(C1CC1)c2ccc(OCCCc3c[nH]cn3)cc2
InChI
1S/C16H18N2O2.ClH/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;/h5-8,10-12H,1-4,9H2,(H,17,18);1H
InChI key
PWAPSKMHZQQTRJ-UHFFFAOYSA-N
Biochem/physiol Actions
Ciproxifan belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.
H3 histamine receptor antagonist.
Features and Benefits
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Questo articolo | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - |
| form solid | form powder | form - | form solid |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 30 mg/mL, water, high purity: 30 mg/mL | solubility DMSO: 32 mg/mL, H2O: insoluble | solubility H2O: 30 mg/mL, clear | solubility H2O: 22 mg/mL at ~60 °C |
| storage condition desiccated, under inert gas | storage condition - | storage condition desiccated | storage condition under inert gas |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Articoli
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The histamine H3 receptor (H3R) is abundantly expressed in the Central Nervous System where it regulates several functions pre and postsynaptically. H3Rs couple to Gαi/o proteins and trigger or modulate several intracellular signaling pathways, including the cAMP/PKA pathway and the
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| C6492-5MG | 04061833511299 |
| C6492-25MG | 04061833511282 |
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Can I store aliquots in -80 °C after diluting it in water?
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