A8843

AM580

≥98% (HPLC), RAR-α agonist, solid

• Sinonimo/i: 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid
• Formula empirica (notazione di Hill): C₂₂H₂₅NO₃
• Numero CAS: 102121-60-8
• Peso molecolare: 351.44
• UNSPSC Code: 12352200
• PubChem Substance ID: 24891374
• NACRES: NA.77
• MDL number: MFCD00673916
• Assay: ≥98% (HPLC)
• Form: solid

Proprietà

• Nome del prodotto: AM580, ≥98% (HPLC)
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: solid
• storage temp.: −20°C
• SMILES string: CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc3ccc(cc3)C(O)=O
• InChI: 1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
• InChI key: SZWKGOZKRMMLAJ-UHFFFAOYSA-N
• Gene Information: human ... RARA(5914), RARB(5915)

Descrizione

General description

AM580 is a retinobenzoic derivative and a RAR-α (retinoic acid receptor-α) agonist. It stimulates the maturation of granulocytes in NB4 promyelocytic leukemia cell line and APL (acute promyelocytic leukemia) blasts. AM580 suppresses endometrial cancer cell proliferation.

Application

Retinoid derivative used for gene expression studies of leukemia-retinoic acid receptor (PHL-RAR) cell line differentiation.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)