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A6478

(R,S)-AM1241

Name: (R,S)-AM1241
Brand: SIGMA

≥98% (HPLC), solid

Sinonimo/i:

(R,S)-3-(2-Iodo-5-nitrobenzoyl)-1-(1-methyl-2-piperidinylmethyl)-1H-indole

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Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₂₂H₂₂IN₃O₃

Numero CAS:

444912-48-5

Peso molecolare:

503.33

NACRES:

NA.77

PubChem Substance ID:

24891092

UNSPSC Code:

12352200

MDL number:

MFCD11045986

Assay:

≥98% (HPLC)

Form:

solid

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Proprietà

Quality Segment

100

assay

≥98% (HPLC)

form

solid

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

yellow

solubility

DMSO: ~18 mg/mL at 60 °C

SMILES string

CN1CCCCC1Cn2cc(C(=O)c3cc(ccc3I)[N+]([O-])=O)c4ccccc24

InChI

1S/C22H22IN3O3/c1-24-11-5-4-6-16(24)13-25-14-19(17-7-2-3-8-21(17)25)22(27)18-12-15(26(28)29)9-10-20(18)23/h2-3,7-10,12,14,16H,4-6,11,13H2,1H3

InChI key

ZUHIXXCLLBMBDW-UHFFFAOYSA-N

Descrizione

Application

(R,S)-AM1241 has been used as a cannabinoid CB2 agonist:

to study its inhibitory effect on bone cancer-induced pain and bone loss
to study the effect of its interaction with 17βestradiol on proliferation activity in primary human osteoblasts
to evaluate the sites of CB2 mediated antinociception in vivo.

Biochem/physiol Actions

Selective CB₂ cannabinoid receptor agonist

AM1241 acts as an antinociceptive agent in several animal pain models. It has a potential to delay disease progression in amyotrophic lateral sclerosis (ALS) mouse model. Intrathecal, intravenous or intraperitoneal administration of AM1241 reduces hyperalgesia and allodynia in neuropathic rats.

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Questo articolo	G5918	SML2769	SML0204
Sigma-Aldrich A6478 (R,S)-AM1241	Sigma-Aldrich G5918 GR 113808	Sigma-Aldrich SML2769 ASS234	Sigma-Aldrich SML0204 MS-1020
form solid	form solid	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
drug control regulated under CDSA - not available from Sigma-Aldrich Canada	drug control -	drug control -	drug control -
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
solubility DMSO: ~18 mg/mL at 60 °C	solubility DMSO: >20 mg/mL	solubility DMSO: 2 mg/mL, clear	solubility DMSO: ≥10 mg/mL at 60 °C
color yellow	color white to light pink	color white to beige	color white to tan