G5918

GR 113808

≥98% (HPLC), solid

• Sinonimo/i: 1-[2-[(Methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl 1-methyl-1H-indole-3-carboxylate
• Formula empirica (notazione di Hill): C₁₉H₂₇N₃O₄S
• Numero CAS: 144625-51-4
• Peso molecolare: 393.50
• Numero MDL: MFCD00912901
• Codice UNSPSC: 12352200
• ID PubChem: 24278311
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: solid
• Colore: white to light pink
• Solubilità: DMSO: >20 mg/mL
• Ideatore: GlaxoSmithKline
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c3ccccc13
• InChI: 1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3; MOZPSIXKYJUTKI-UHFFFAOYSA-N
• Informazioni sul gene: human ... HTR4(3360) ; rat ... Htr3a(79246) , Htr4(25324)

Descrizione

Applicazioni

GR 113808 has been used as a serotonin receptor 4 (5-HT4R) blocker to study its effects on the calcium (Ca²⁺) transients in rat ventricular cardiomyocytes.[1] It has also been used as a 5-HT4R antagonist to study its effects on de novo enteric neurogenesis in post-embryonic zebrafish.[2]

Azioni biochim/fisiol

GR 113808 is a 5-HT₄ serotonin receptor antagonist.

Caratteristiche e vantaggi

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Note legali

Sold for research purposes under agreement from Glaxo­Smith­Kline

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)