SML0204

MS-1020

≥98% (HPLC)

• Sinonimo/i: 1-Hydroxy-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-naphtamide, 1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide
• Formula empirica (notazione di Hill): C₂₁H₁₈N₂O₃
• Numero CAS: 1255516-86-9
• Peso molecolare: 346.38
• Codice UNSPSC: 12352202
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to tan
• Solubilità: DMSO: ≥10 mg/mL at 60 °C
• Temperatura di conservazione: 2-8°C

Descrizione

Applicazioni

MS-1020 may be used in JAK-3-mediated cell signaling studies.

Azioni biochim/fisiol

MS-1020 is a selective JAK3 inhibitor

MS-1020 is an ATP-competitive, selective inhibitor of JAK3, thereby blocking downstream STAT signaling. MS-1020 binds directly with JAK3, blocking its catalytic activity. It suppressed IL-2-induced JAK3/STAT5 signaling but not prolactin-induced JAK2/STAT5 signaling. MS-1020 has also been shown to decreases cell survival by inducing apoptosis via downregulating anti-apoptotic gene expression.

Caratteristiche e vantaggi

This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H319
• Consigli di prudenza: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Eye Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable