V116

Z-VAD-FMK

≥98% (TLC), solid, Caspase inhibitor

• Sinonimo/i: N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone
• Formula empirica (notazione di Hill): C₂₂H₃₀FN₃O₇
• Numero CAS: 187389-52-2
• Peso molecolare: 467.49
• Numero MDL: MFCD01074990
• Codice UNSPSC: 12352209
• NACRES: NA.77

Proprietà

• Nome del prodotto: Z-VAD-FMK, solid
• Origine biologica: synthetic
• Saggio: ≥98% (TLC)
• Stato: solid
• Colore: white
• Solubilità: DMSO: 20 mg/mL; H₂O: insoluble
• Temperatura di conservazione: −20°C
• Stringa SMILE: FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C)CC(=O)OC
• InChI: 1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1; MIFGOLAMNLSLGH-QOKNQOGYSA-N
• Informazioni sul gene: human ... CASP3(836) ; mouse ... CASP3(12367) ; rat ... CASP3(25402)

Descrizione

Descrizione generale

Z-VAD-FMK inhibits yeast and mammalian peptide N-glycanase (PNGase).[1] It induces apoptosis. Z-VAD-FMK might be associated with endoplasmic reticulum (ER) stress.[2]

Applicazioni

Z-VAD-FMK has been used:

• to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells[3]
• to induce autophagy in Jurkat and K562 cells[4]
• to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines[5]
• as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53[6]

Azioni biochim/fisiol

Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.

Caratteristiche e vantaggi

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Avvertenza

Hygroscopic

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)