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G002

Sigma-Aldrich

Isoguvacine hydrochloride

solid

Sinonimo/i:

1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C6H9NO2 · HCl
Numero CAS:
68547-97-7
Peso molecolare:
163.60
Numero MDL:
MFCD00055192
Codice UNSPSC:
12352200
ID PubChem:
24278160
NACRES:
NA.77

Forma fisica

solid

Colore

white

Solubilità

H2O: soluble (refrigerate if not used immediately.)
methanol: slightly soluble
neutral and acidic solutions: stable (in basic solutions the free amine can oxidize easily)

Stringa SMILE

Cl[H].OC(=O)C1=CCNCC1

InChI

1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5;/h1,7H,2-4H2,(H,8,9);1H
SUWREQRNTXCCBL-UHFFFAOYSA-N

Informazioni sul gene

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562)

Applicazioni

Isoguvacine hydrochloride has been used as a γ-aminobutyric acid type A (GABAA) receptor agonist:
  • to study its effects on neuronal activity in rats
  • to study its antiallodynic effect in rats
  • to study its effects on baroreflex gains in rats

Azioni biochim/fisiol

Isoguvacine is a strong γ-aminobutyric acid A (GABAA) receptor agonist.

Caratteristiche e vantaggi

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

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Sigma-Aldrich

S106

SR-95531

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(+)-Bicuculline ≥97.0% (TLC)

Sigma-Aldrich

14340

(+)-Bicuculline

Laura Lagostena et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(3), 885-893 (2010-01-22)
GABA, the main inhibitory transmitter in adulthood, early in postnatal development exerts a depolarizing and excitatory action. This effect, which results from a high intracellular chloride concentration ([Cl(-)](i)), promotes neuronal growth and synaptogenesis. During the second postnatal week, the developmental
Kai Y Fan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(40), 13718-13728 (2012-10-05)
The symptoms of Parkinson's disease (PD) are related to changes in the frequency and pattern of activity in the reciprocally connected GABAergic external globus pallidus (GPe) and glutamatergic subthalamic nucleus (STN). In idiopathic and experimental PD, the GPe and STN
Palakodety Radha Krishna et al.
Journal of combinatorial chemistry, 10(3), 426-435 (2008-04-16)
The preparation of chiral tetrahydropyridine-4-carboxylates as isoguvacine analogues and azasugars with a tertiary stereocenter from L-amino acids via diastereoselective a Baylis-Hillman reaction of N-allyl-Boc alpha-aminal, followed by ring-closing metathesis and dihydroxylation sequences, is reported.
Intracapsular technique of transplant nephrectomy
D E Sutherland, et al.
Surgery, Gynecology & Obstetrics, 146(6), 950-952 (1978)
Jen-Kun Cheng et al.
Anesthesia and analgesia, 102(1), 182-187 (2005-12-22)
Gabapentin is a novel analgesic whose mechanism of action is not known. We investigated in a postoperative pain model whether adenosine triphosphate (ATP)-sensitive K+ (K(ATP)) channels, N-methyl-d-aspartic acid (NMDA) receptors, and Ca2+ channels are involved in the antiallodynic effect of
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