F3422
Flt-3/Flk-2 ligand human
recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥98% (SDS-PAGE and HPLC)
Sinonimo/i:
FL
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5 μG
251,00 €
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Cambia visualizzazione
5 μG
251,00 €
About This Item
Prodotti consigliati
Origine biologica
human
Livello qualitativo
Ricombinante
expressed in E. coli
Saggio
≥98% (SDS-PAGE and HPLC)
Stato
lyophilized powder
Potenza
≤1.0 ng/mL
PM
17.6 kDa
Confezionamento
pkg of 5 μg
Condizioni di stoccaggio
avoid repeated freeze/thaw cycles
tecniche
cell culture | mammalian: suitable
Impurezze
endotoxin, tested
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... FLT3(2322)
Descrizione generale
Mouse and human Flt-3 ligand share ~72% homology and both demonstrate cross-species activity.
Azioni biochim/fisiol
Flt-3/Flk-2 Ligand (FL, or Flt-3L) is a transmembrane glycoprotein that binds and activates the Flt-3 receptor. Expression of Flt-3 is primarily restricted among hematopoietic cells to the most primitive progenitor cells.
Stato fisico
Lyophilized, 0.2 μm sterile filtered, with with 0.5x PBS.
Risultati analitici
The biological activity is measured by its ability to stimulate the proliferation of human AML5 cells.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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R Namikawa et al.
Stem cells (Dayton, Ohio), 14(4), 388-395 (1996-07-01)
The biological activities of the ligand for the Flk2/Flt3 receptor tyrosine kinase (FL) on human hematopoietic cells are reviewed. In in vitro studies, FL shows relatively few effects by itself on the proliferation and differentiation of hematopoietic cells, but exhibits
Lyman, S., et al. et al.
The Cytokine Handbook, 727-727 (1998)
H G Drexler et al.
Leukemia & lymphoma, 33(1-2), 83-91 (1999-04-08)
FLT3 ligand (FL) acting through its tyrosine kinase receptor FLT3 has pleiotropic and potent effects on hematopoietic cells. The well-described involvement of this ligand-receptor pair in physiological hematopoiesis raised the question whether FL and FLT3 also play a role in
S D Lyman et al.
Oncogene, 8(4), 815-822 (1993-04-01)
We have developed rabbit polyclonal antibodies to the C-terminus of the flt3-encoded protein, which is a member of the receptor tyrosine kinase family. Immunoprecipitation using this antiserum brings down two protein bands, a major band of 143 kDa and a
O Rosnet et al.
Oncogene, 6(9), 1641-1650 (1991-09-01)
Receptor-type tyrosine kinases presenting an extracellular region with five immunoglobulin-like domains, and strongly related by sequence similarities in the intracellular region, constitute a family of receptors involved in development and function of various cell lineages. We have isolated and characterized
Articoli
Read article on hematopoietic cytokines and hematopoiesis
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