H5416
FLT3 Ligand human
HumanKine®, recombinant, expressed in HEK 293 cells, suitable for cell culture
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10 μG
335,00 €
335,00 €
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Cambia visualizzazione
10 μG
335,00 €
About This Item
335,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Prodotti consigliati
Nome del prodotto
FLT3 Ligand human, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
Origine biologica
human
Livello qualitativo
Ricombinante
expressed in HEK 293 cells
Saggio
≥95% (SDS-PAGE)
Stato
lyophilized powder
Potenza
≤0.8 ng/mL EC50
Qualità
endotoxin tested
PM
monomer 24-30 kDa (glycosylated)
Confezionamento
pkg of 10 μg
Condizioni di stoccaggio
avoid repeated freeze/thaw cycles
tecniche
cell culture | mammalian: suitable
Impurezze
≤1 EU/mg
Temperatura di conservazione
−20°C
Descrizione generale
Azioni biochim/fisiol
FLT3 ligand binds to the cell-bound tyrosine kinase receptor and activates them.[2]
HumanKine FLT3 Ligand is expressed in human HEK 293 cells as a glycosylated monomer with an apparent molecular mass of 24-30 kDa. HumanKine FLT3 Ligand in human HEK 293 cells contributes to glycosylation.FLT3 ligand is a hematopoietic cytokine that regulates the proliferation of early hematopoietic cells. It has been shown to synergize with a variety of cytokines to stimulate the growth and differentiation of early hematopoietic cells. The FLT3 ligand also stimulates the expansion of monocytes and immature dendritic cells, and induces early B cell lineage differentiation and NK cell growth.
Stato fisico
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
Risultati analitici
The specific activity was determined by the dose-dependent stimulation of the proliferation of the human acute myeloid leukemia cell line OCI-AML5.
Note legali
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots
Savvides S N, et al.
Nature Structural and Molecular Biology, 7(6), 486-486 (2000)
Nobuyuki Onai et al.
Annals of the New York Academy of Sciences, 1106, 253-261 (2007-03-16)
Flt3-ligand is a nonredundant cytokine in type I interferon-producing cell (IPC) and dendritic cell (DC) development. We demonstrated that IPC and DC differentiation potential is confined to Flt3(+)-hematopoietic progenitor cells, that Flt3-ligand drives development along both lymphoid and myeloid developmental
Structure-function analysis of FLT3 ligand-FLT3 receptor interactions using a rapid functional screen
Graddis T, et al.
The Journal of Biological Chemistry, 273(28), 17626-17633 (1998)
Chunaram Choudhary et al.
International journal of hematology, 82(2), 93-99 (2005-09-09)
Activating mutations of Fms-like tyrosine kinase 3 (Flt3) are the most common genetic lesions in acute myeloid leukemia (AML) and are present in approximately one third of AML patients. The 2 classes of Flt3 mutations are internal tandem duplications in
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