This product is the full-length, unmodified, native protein from human serum. Complement C7 is a naturally glycosylated protein composed of a single polypeptide chain of 92,400 Da.
C2787
Complement C7 from human serum
≥85% (SDS-PAGE), ≥150,000 C7H50 units/mg protein
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Scegli un formato
0.1 MG
486,00 €
Scegli un formato
Cambia visualizzazione
0.1 MG
486,00 €
About This Item
Prodotti consigliati
Origine biologica
human serum
Livello qualitativo
Saggio
≥85% (SDS-PAGE)
Stato
solution
Attività specifica
≥150,000 C7H50 units/mg protein
Concentrazione
1 mg/mL in 10 mM sodium phosphate, 150 mM sodium chloride, pH 7.2
tecniche
activity assay: suitable
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... C7(730)
Azioni biochim/fisiol
The complement system is a complex cascade involving proteolytic cleavage of serum glycoproteins often activated by cell receptors. This cascade ultimately results in induction of the inflammatory response, phagocyte chemotaxis and opsonization, and cell lysis.
A complex of complements C5b, C6, C7, and C8 mediates the polymerization of up to eighteen C9 molecules into a tube-like membrane attack complex that is inserted into the plasma membrane of unwanted organisms, such as of Gram-negative bacteria and viral infected cells. This channel through the lipid bilayer results in lysis of the cell.
Human Complement C7 is a β-2-globulin, which is composed of a single polypeptide chain. The initial binding of C7 and C6 to C5b is thought to form a stable complex for subsequent binding of C8 and C9. The resulting activated complex is responsible for membrane attack and lysis.
A complex of complements C5b, C6, C7, and C8 mediates the polymerization of up to eighteen C9 molecules into a tube-like membrane attack complex that is inserted into the plasma membrane of unwanted organisms, such as of Gram-negative bacteria and viral infected cells. This channel through the lipid bilayer results in lysis of the cell.
Human Complement C7 is a β-2-globulin, which is composed of a single polypeptide chain. The initial binding of C7 and C6 to C5b is thought to form a stable complex for subsequent binding of C8 and C9. The resulting activated complex is responsible for membrane attack and lysis.
Qualità
Functionally active by a sensitive hemolytic assay.
Esclusione di responsabilità
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
A F Esser
Toxicology, 87(1-3), 229-247 (1994-02-28)
The membrane attack complex of complement is formed by the molecular fusion of the five terminal complement proteins, C5, C6, C7, C8, and C9. While the assembly process on a target membrane and its modulation by restriction factors present on
-
I would like to know if the product is a full sequence protein (92.4 kDa, 843 AA)?
1 risposta-
Utile?
-
Filtri attivi
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.
