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C8195

Complement C4 from human serum

≥300,000 C4H50 units/mg protein

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0.1 mg
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494,00 €

Informazioni su questo articolo

Numero CAS:
80295-48-3
UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00130838
Form:
solution
Biological source:
human serum

494,00 €

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biological source

human serum

Quality Segment

200

form

solution

specific activity

≥300,000 C4H50 units/mg protein

technique(s)

activity assay: suitable

UniProt accession no.

P0C0L4

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... C4A(720)

General description

Complement C4 is mapped to human chromosome 6p21.33. It exists in two isoforms as c4A and c4B. C4 is a 200 kDa protein belonging to α2 macroglobulin (α2M) family. It undergoes posttranslational modification like sulfation and glycosylation and finally proteolysis to become a mature protein.

Application

Complement C4 from human serum has been used in mannose binding lectin (MBL) complex assay of serum samples and in MBL-associated serine proteases based C4 activation assay of plasma samples.

Biochem/physiol Actions

There are strong indications that complement C4 deficiency is correlated with induction of systemic lupus erythematosus (SLE) and other autoimmune diseases.
Complement C4 serves a primary role in the classical and lectin pathways of the complement system and provides protection against bacterial pathogens. C4 polymorphisms have been used in research to study their associations with the hemolytic and antibacterial ability of the classical pathway.
Variation in the copy number of the complement C4 gene alters the complement c4A and c4B levels in age-related macular degeneration (AMD) and increases risk of developing schizophrenia.

Physical form

Supplied as a solution in PBS, pH 7.2

Other Notes

View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

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Questo articolo
204886C2787C3160
Complement C4 from human serum ≥300,000 C4H50 units/mg protein

Sigma-Aldrich

C8195

Complement C4 from human serum

Complement C4, Human Complement C4, Human, CAS 80295-48-3,is a native glycoprotein composed of three non-identical subunits of 93, 75, and 32 kDa linked by disulfide bonds.

Sigma-Aldrich

204886

Complement C4, Human

Complement C7 from human serum ≥85% (SDS-PAGE), ≥150,000 C7H50 units/mg protein

Sigma-Aldrich

C2787

Complement C7 from human serum

Complement C5 from human serum ≥90% (SDS-PAGE), >100,000 C5H50 units/mg protein

Sigma-Aldrich

C3160

Complement C5 from human serum

description

≥300,000 C4H50 units/mg protein

description

Complement C4, Human, CAS 80295-48-3,is a native glycoprotein composed of three non-identical subunits of 93, 75, and 32 kDa linked by disulfide bonds.

description

≥85% (SDS-PAGE), ≥150,000 C7H50 units/mg protein

description

≥90% (SDS-PAGE), >100,000 C5H50 units/mg protein

biological source

human serum

biological source

-

biological source

human serum

biological source

human serum

technique(s)

activity assay: suitable

technique(s)

-

technique(s)

activity assay: suitable

technique(s)

activity assay: suitable

form

solution

form

liquid

form

solution

form

solution

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

specific activity

≥300,000 C4H50 units/mg protein

specific activity

>3X105 C4H50 units/mg protein

specific activity

≥150,000 C7H50 units/mg protein

specific activity

>100,000 C5H50 units/mg protein

UniProt accession no.

P0C0L4

UniProt accession no.

-

UniProt accession no.

P10643

UniProt accession no.

P01031

Classe di stoccaggio

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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  1. How does the storage temperature relate to shipping conditions?

    1 risposta

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

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  2. What is the molecular weight of Product C8195, Complement C4 from human serum?

    1 risposta

    1. The molecular weight for Product C8195, Complement C4 from human serum, is 205,000 daltons as described in Complement: A Practical Approach, A.W. Dodds and R.B. Sim, Eds., p. 2, 1997.

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  3. What is the Department of Transportation shipping information for this product?

    1 risposta

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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