Documenti fondamentali

Visualizza tutta la documentazione

Vai a

C199

CGS-15943

Name: CGS-15943
Brand: SIGMA

≥98% (HPLC), Adenosine receptor antagonist, solid

Sinonimo/i:

9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

Autenticati per visualizzare i prezzi organizzativi e contrattuali.

Scegli un formato

Cambia visualizzazione

Taglio della confezione	SKU	Disponibilità	Prezzo

Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₁₃H₈ClN₅O

Numero CAS:

104615-18-1

Peso molecolare:

285.69

UNSPSC Code:

12352202

PubChem Substance ID:

24277704

NACRES:

NA.77

MDL number:

MFCD01529897

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Prezzi e disponibilità al momento non sono disponibili

Servizio Tecnico

Hai bisogno di aiuto? Il nostro team di scienziati qualificati è a tua disposizione.

Permettici di aiutarti

Nome del prodotto

CGS-15943, solid

assay

≥98% (HPLC)

Quality Level

100

form

solid

color

white

solubility

DMSO: >10 mg/mL, H₂O: insoluble

storage temp.

room temp

SMILES string

Nc1nc2ccc(Cl)cc2c3nc(nn13)-c4ccco4

InChI

1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16)

InChI key

MSJODEOZODDVGW-UHFFFAOYSA-N

Categorie correlate

Bioactive Small Molecules

Confronta articoli simili

Visualizza il confronto per intero

Mostra le differenze

1 of 1

Questo articolo	S4568	S6451	Z0153
Sigma-Aldrich C199 CGS-15943	Sigma-Aldrich S4568 SCH 58261	Sigma-Aldrich S6451 SCH-442416	Sigma-Aldrich Z0153 ZM 241385
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form solid	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. room temp	storage temp. -	storage temp. 2-8°C	storage temp. room temp
solubility DMSO: >10 mg/mL, H₂O: insoluble	solubility DMSO: soluble >10 mg/mL, H₂O: insoluble	solubility DMSO: ≥20 mg/mL	solubility DMSO: >15 mg/mL
color white	color off-white	color light tan to tan	color white to tan

Application

CGS-15943 has been used as a non-selective adenosine receptor antagonist to study its effects on the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and hepatocellular carcinoma (HCC)[1]. It has also been used as a non-selective adenosine receptor antagonist to investigate the mechanism underlying adenosine inhibition on cholangiocarcinoma (CCA) cells.[2]

Biochem/physiol Actions

CGS-15943 is a potent and non-selective adenosine receptor antagonist. It exhibits anti-carcinogenic and anti-apoptotic activity.[1]

ppe

Eyeshields, Gloves, type N95 (US)

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

0000364481

0000216290

0000209086

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Adenosine A2a receptors increase arterial endothelial cell nitric oxide.

J m Li et al.

The Journal of surgical research, 80(2), 357-364 (1999-01-08)

Adenosine is a potent vasodilator of vascular smooth muscle. Endothelium-derived nitric oxide (NO) elicits vasodilation. We have previously reported that adenosine stimulates the production of NO from porcine carotid arterial endothelial cells (PCAEC) via a receptor-mediated mechanism. This study was

Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors.

E Ongini et al.

Naunyn-Schmiedeberg's archives of pharmacology, 359(1), 7-10 (1999-02-05)

Three structurally related non-xanthine compounds, CGS 15943, ZM 241385 and SCH 58261, are potent A2A adenosine receptor antagonists and have been used as tools in many pharmacological studies. We have now characterized their affinity and selectivity profile on human adenosine

Biochemical characterization of the triazoloquinazoline, CGS 15943, a novel, non-xanthine adenosine antagonist.

M Williams et al.

The Journal of pharmacology and experimental therapeutics, 241(2), 415-420 (1987-05-01)

CGS 15943A, a triazoloquinazoline, is a potent and selective adenosine receptor antagonist as assessed by its effects on radioligand binding and adenosine-stimulated adenylate cyclase activity in guinea pig synaptoneurosomes. At the adenosine A-1 receptor labeled with [3H]cyclohexyladenosine, CGS 15943A had

Receptor subtypes mediating adenosine-induced dilation of cerebral arterioles.

A C Ngai et al.

American journal of physiology. Heart and circulatory physiology, 280(5), H2329-H2335 (2001-04-12)

The purpose of this study was to investigate the receptor subtypes that mediate the dilation of rat intracerebral arterioles elicited by adenosine. Penetrating arterioles were isolated from the rat brain, cannulated with the use of a micropipette system, and luminally

Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.

Lazaros C Foukas et al.

The Journal of biological chemistry, 277(40), 37124-37130 (2002-07-30)

We investigated the effects of methylxanthines on enzymatic activity of phosphoinositide 3-kinases (PI3Ks). We found that caffeine inhibits the in vitro lipid kinase of class I PI3Ks (IC(50) = 75 microm for p110 delta, 400 microm for p110 alpha and

Visualizza tutti i documenti correlati

Numero articolo commerciale globale

SKU	GTIN
C199-25MG	04061833474914

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica