A8016

Adenosine 5′-[β-thio]diphosphate trilithium salt

≥80% (HPLC), P2Y receptor agonist., powder

• Sinonimo/i: ADP-β-S, Adenosine-5′-0-(2-thiodiphosphate) trilithium salt, Ado-5′-PP[S]
• Formula empirica (notazione di Hill): C₁₀H₁₂Li₃N₅O₉P₂S
• Numero CAS: 73536-95-5
• Peso molecolare: 461.07
• UNSPSC Code: 41106305
• eCl@ss: 32160414
• PubChem Substance ID: 24891307
• NACRES: NA.77
• MDL number: MFCD00077314
• Assay: ≥80% (HPLC)
• Form: powder
• Quality level: 200

Proprietà

• Nome del prodotto: Adenosine 5′-[β-thio]diphosphate trilithium salt, ≥80% (HPLC)
• Quality Level: 200
• assay: ≥80% (HPLC)
• form: powder
• storage temp.: −20°C
• SMILES string: [Li+].[Li+].[Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O
• InChI: 1S/C10H15N5O9P2S.3Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(23-10)1-22-25(18,19)24-26(20,21)27;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H2,20,21,27);;;/q;3*+1/p-3/t4-,6-,7-,10-;;;/m1.../s1
• InChI key: CPKFUAYUUSSFFZ-MSQVLRTGSA-K

Descrizione

General description

Substrate and inhibitor for AMP dependent enzyme systems.

Application

Adenosine 5′-[β-thio]diphosphate is a substrate and inhibitor for AMP dependent enzyme systems. Adenosine 5′-[β-thio]diphosphate has been used to explore the myenteric control mechanisms of human esophageal motility and the effect of nitrergic and nonnitrergic neurotransmitters.

Adenosine 5′-[β-thio]diphosphate trilithium salt has been used to induce neuropathic pain in rats to study the effect of dorsal horn cannabinoid CB2 receptor activation on the expression of P2Y12 and P2Y13 (purinoceptors) receptors.

Biochem/physiol Actions

P2Y receptor agonist.

Features and Benefits

This compound is featured on the P2 Receptors: P2Y G-Protein Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Non-hydrolyzable ADP analog

Informazioni sulla sicurezza

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H371
• pcodes: P260 - P264 - P301 + P312 - P308 + P311 - P405 - P501
• Hazard Classifications: Acute Tox. 4 Oral - STOT SE 2
• target_organs: Eyes,Central nervous system
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves