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29447

(24S)-24,25-Dihydroxyvitamin D3

≥95.0% (HPLC)

Sinonimo/i:

(24S)-24,25-Dihydroxycholecalciferol

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Informazioni su questo articolo

Formula empirica (notazione di Hill):
C27H44O3
Numero CAS:
Peso molecolare:
416.64
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:


Quality Level

assay

≥95.0% (HPLC)

form

powder or crystals

color

colorless to white

mp

114.6 °C

storage temp.

−20°C

SMILES string

C[C@H](CC[C@H](O)C(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C

InChI

1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22+,23-,24+,25+,27-/m1/s1

InChI key

FCKJYANJHNLEEP-WQUHCOROSA-N

Biochem/physiol Actions

Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 24S,25-Dihydroxyvitamin D3 should not be confused with 24R,25-Dihydroxyvitamin D3.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.


pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 2 Oral

Classe di stoccaggio

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges



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José Pérez Sestelo et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 8(12), 2747-2752 (2002-10-24)
Vitamin D3 active metabolites 24R,25-(OH)2-D3, 24S,25-(OH)2-D3, and 1 alpha, 24R,25-(OH)3-D3 were synthesized by a convergent and stereoselective approach. In the synthetic route, the stereogenic center at C-24 was generated through ultrasonically induced aqueous conjugate addition of iodide 6 to Seebach's
H L Henry et al.
The Journal of nutrition, 106(6), 724-734 (1976-06-01)
The ability of 24R, 25- and 24S, 25-dihydroxycholecalciferol to stimulate intestinal calcium transport and bone calcium mobilization in chicks was measured. Enhancement of intestinal calcium transport by 325 or 130 nmoles of either compound was maximal by 24 hours. The
Anjali Verma et al.
Steroids, 150, 108447-108447 (2019-07-16)
Vitamin D has long been prescribed as a supplement to breast cancer patients. This is partially motivated by data indicating that low serum vitamin D, measured as 25-hydroxyvitamin D3 [25(OH)D3], is associated with worsened cancer prognosis and decreased survival rates



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