42579
4-Phenyl-1,2,4-triazoline-3,5-dione
for HPLC derivatization, LiChropur™, ≥98.0% (CHN)
Sinonimo/i:
Cookson reagent, 4-Phenyl-3H-1,2,4-triazole-3,5(4H)-dione, PTAD
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About This Item
Formula empirica (notazione di Hill):
C8H5N3O2
Numero CAS:
Peso molecolare:
175.14
Beilstein:
141548
Numero CE:
Numero MDL:
Codice UNSPSC:
41116105
ID PubChem:
NACRES:
NA.22
Prodotti consigliati
Grado
for HPLC derivatization
Livello qualitativo
Saggio
≥98.0% (CHN)
Qualità
LiChropur™
tecniche
HPLC: suitable
Punto di fusione
165-170 °C (dec.) (lit.)
Temperatura di conservazione
2-8°C
Stringa SMILE
O=C1N=NC(=O)N1c2ccccc2
InChI
1S/C8H5N3O2/c12-7-9-10-8(13)11(7)6-4-2-1-3-5-6/h1-5H
ISULLEUFOQSBGY-UHFFFAOYSA-N
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Descrizione generale
4-Phenyl-1,2,4-triazoline-3,5-dione, also known as Cookson reagent, is a strong dienophile, which gives a stable Diels-Alder adduct quantitatively within a short time and under mild conditions. It is commonly used as a protecting group of the diene moiety for the synthesis of vitamin D3 (VD3)-related compounds.
Applicazioni
4-Phenyl-1,2,4-triazoline-3,5-dione may be used as a derivatizing reagent for the determination of trace levels of 25-hydroxyvitamin D and its C-3 epimer in biological samples and cholecalciferol (vitamin D3) in fortified infant formula, milk and milk powder using liquid chromatography–tandem mass spectrometry (LC–MS/MS)technique.
Note legali
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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A S Weiskopf et al.
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Simultaneous and accurate measurement of vitamin D and 25-hydroxyvitamin D in biological samples is a barrier limiting our ability to define "optimal" vitamin D status. Thus, our goal was to optimize conditions and evaluate an LC-MS method for simultaneous detection
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