1.02442

Cloroformio

for analysis (for determinations with dithizone)

• Sinonimo/i: Triclorometano, Tricloruro di metilidina
• Formula empirica (notazione di Hill): CHCl₃
• Numero CAS: 67-66-3
• Peso molecolare: 119.38
• UNSPSC Code: 12191502
• NACRES: NA.21
• EC Index Number: 200-663-8
• MDL number: MFCD00000826
• Beilstein/REAXYS Number: 1731042
• Assay: 99.0-99.4% (GC)
• Bp: 60.5-61.5 °C (lit.)
• Vapor pressure: 160 mmHg ( 20 °C)

Proprietà

• vapor density: 4.1 (vs air)
• Quality Level: 300
• vapor pressure: 160 mmHg ( 20 °C)
• assay: 99.0-99.4% (GC)
• form: liquid
• potency: 695 mg/kg LD₅₀, oral (Rat), >3980 mg/kg LD₅₀, skin (Rabbit)
• dilution: (for analytical testing)
• impurities: ≤0.0001% Chloride (Cl), ≤0.001% Free acid (as HCl), ≤0.005% Carbonyl compounds (as CO), ≤0.01% Carbon tetrachloride (GC), ≤0.01% Dichloromethane (GC), ≤0.01% Tetrachloroethylene (GC), ≤0.01% Trichloroethylene (GC), ≤0.01% Water, 0.6-1% Ethanol (GC), 0.6-1.0% Ethanol (GC)
• evapn. residue: ≤0.001%
• refractive index: n20/D 1.445 (lit.)
• bp: 60.5-61.5 °C (lit.)
• mp: −63 °C (lit.)
• density: 1.492 g/mL at 25 °C (lit.)
• cation traces: Al: ≤0.00005%, B: ≤0.000002%, Ba: ≤0.00001%, Ca: ≤0.00005%, Cd: ≤0.000005%, Co: ≤0.000002%, Cr: ≤0.000002%, Cu: ≤0.000002%, Fe: ≤0.00001%, Mg: ≤0.00001%, Mn: ≤0.000002%, Ni: ≤0.000002%, Pb: ≤0.00001%, Sn: ≤0.00001%, Zn: ≤0.00001%
• storage temp.: 2-30°C
• SMILES string: ClC(Cl)Cl
• InChI: 1S/CHCl3/c2-1(3)4/h1H
• InChI key: HEDRZPFGACZZDS-UHFFFAOYSA-N

Descrizione

Application

• Characterization of Natural Products: Chloroform is extensively used in the extraction and isolation of natural products. A study on the characterization and pesticidal evaluation of diterpenes isolated from chloroform extracts of Hedychium spicatum rhizomes highlights its effectiveness. This application is crucial for identifying bioactive compounds and assessing their potential uses in pharmaceuticals and agrochemicals (Rawat et al., Analytical Chemistry Letters, 2023).


• Self-Diffusion and Molecular Association Studies: Chloroform is used in studies of self-diffusion and molecular association in binary systems, such as dimethyl sulfoxide (DMSO) and acetone. These studies provide insights into the molecular interactions and dynamics in mixed solvents, which are essential for understanding solvation and reaction mechanisms in various chemical processes (Gurina and Golubev, Results in Chemistry, 2022).


• Cell-Free DNA Isolation: A novel phenol-chloroform-free method for isolating cell-free DNA from cell-conditioned media has been developed, optimized, and compared with traditional methods. This advancement is significant for genomic studies, allowing for more efficient and less hazardous extraction of nucleic acids from biological samples (Das et al., Analytical Biochemistry, 2024).


• Green Chemistry and Circular Economy: Chloroform plays a role in green analytical chemistry, particularly in the development of circular chemistry principles. Research emphasizes the need to design chemical processes that minimize waste and environmental impact, promoting sustainability in analytical laboratories. This includes the use of chloroform in recyclable and reusable systems to reduce solvent waste (Psillakis and Pena-Pereira, TrAC Trends in Analytical Chemistry, 2024).

Other Notes

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Informazioni sulla sicurezza

• pictograms: GHS06,GHS08
• signalword: Danger
• pcodes: P202 - P301 + P312 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
• wgk: WGK 3
• flash_point_f: does not flash
• flash_point_c: does not flash
• hcodes: H302,H315,H319,H331,H336,H351,H361d,H372
• target_organs: Central nervous system, Liver,Kidney
• Classe di stoccaggio: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects