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Informazioni su questo articolo
Formula empirica (notazione di Hill):
C24H34N4O2S
Numero CAS:
Peso molecolare:
442.62
NACRES:
NA.77
UNSPSC Code:
12352204
Per informazioni sul prodotto SML1879, contatta il rappresentante o rivenditore Merck di zona. Contatta l'Assistenza Tecnica
Servizio Tecnico
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Permettici di aiutartiQuality Level
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +1.0 to +3.0°, c = 1 in chloroform-d
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
A-395N is a control probe for A-395, which is a chemical probe for polycomb protein EED. A-395 is a potent and selective chemical probe for the polycomb protein EED (embryonic ectoderm development), an essential component of Polycomb repressive complex 2 (PRC2), involved in transcriptional repression through methylation of histone H3K27. A-395N is structurally similar, but exhibits no activity in the biochemical and cellular assays, so is an ideal control compound. For characterization details of the active probe, A-395, please visit the A-395 probe summary on the Structural Genomics Consortium (SGC) website.
A-395, the active enantiomer, is available from Sigma. To learn more about and purchase A-395, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
A-395, the active enantiomer, is available from Sigma. To learn more about and purchase A-395, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
A-395N is a control probe for A-395, which is a chemical probe for polycomb protein EED..
Features and Benefits
A-395N is a negative control for A-395, an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
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Questo articolo | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 10 mg/mL, clear | solubility H2O: 10 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 10 mg/mL, clear |
| color white to beige | color white to light brown | color white to beige | color white to beige |
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
Classe di stoccaggio
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Mélanie Criqui et al.
eLife, 9 (2020-04-17)
The precise relationship between epigenetic alterations and telomere dysfunction is still an extant question. Previously, we showed that eroded telomeres lead to differentiation instability in murine embryonic stem cells (mESCs) via DNA hypomethylation at pluripotency-factor promoters. Here, we uncovered that
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| SML1879-25MG | 04061832639154 |
| SML1879-5MG | 04061832639161 |




