SML3281

GSK215 hydrochloride

≥98% (HPLC)

• Sinonimo/i: (2S,4R)-4-hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-(4-(2-(methylcarbamoyl)phenylamino)-5-(trifluoromethyl)pyridin-2-ylamino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride, GSK 215 hydrochloride, GSK-215 hydrochloride
• Formula empirica (notazione di Hill): C₅₀H₅₉F₃N₁₀O₆S · xHCl
• Peso molecolare: 985.13 (free base basis)
• Numero MDL: MFCD34574613
• Codice UNSPSC: 51111800
• Codice UNSPSC: 12352200
• NACRES: NA.21

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Composizione: , 0-8 (H2O); , 1.8-3.3 mol (HCl)
• Condizioni di stoccaggio: desiccated
• Colore: white to beige
• Solubilità: DMSO: 2 mg/mL, clear (warmed)
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: FC(F)(F)c1cnc(cc1Nc7c(cccc7)C(=O)NC)Nc2c(cc(cc2)N3CCN(CC3)CC(=O)N[C@@H](C(C)(C)C)C(=O)N4[C@@H](C[C@H](C4)O)C(=O)N[C@@H](C)c5ccc(cc5)c6[s]cnc6C)OC
• InChI: ZGSWGXNEXAXEGV-XFCHVEHOSA-N

Descrizione

Azioni biochim/fisiol

GSK215 is a potent and selective focal adhesion kinase (FAK) degrader (DC50 = 1.3 nM; A549 cells) composed of the FAK inhibitor VS-4718 and the VHL E3 ligase binder VHL-021. GSK215 shows cell type-dependent growth inhibition, where it inhibits A549 (IC50 <1 µM) and MCF-7 (IC50 <0.1 µM), but not BT474, in 2D cultures, while the growth of BT47 (IC50 <0.1 µM) and MCF-7 (IC50 ~0.1 µM), but not A5494, are inhibited by GSK215 in 3D cultures.

Potent and selective focal adhesion kinase (FAK) degrader composed of the FAK inhibitor VS-4718 and the VHL E3 ligase binder VHL-021.

Avvertenza

Hygroscopic

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable