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N0761

Sigma-Aldrich

Acido nicotinico

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%

Sinonimo/i:

Acido 3-picolinico, Acido piridin-3-carbossilico, Fattore di prevenzione della pellagra, Niacina, Vitamina B3

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About This Item

Formula empirica (notazione di Hill):
C6H5NO2
Numero CAS:
59-67-6
Peso molecolare:
123.11
Beilstein:
109591
Numero CE:
200-441-0
Numero MDL:
MFCD00006391
Codice UNSPSC:
12352207
ID PubChem:
24897443
NACRES:
NA.71

Nome Commerciale

BioReagent

Saggio

≥98%

Forma fisica

powder

PM

Mw 123.11 g/mol

tecniche

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

Colore

white to off-white

pH

3.4 (20 °C, 10 g/L)

Punto di fusione

236-239 °C (lit.)

Solubilità

1 M NaOH: soluble 50 mg/mL, clear, colorless to very faintly yellow

Densità

1.473 g/cm3 at 25 °C

applicazioni

agriculture

Stringa SMILE

OC(=O)c1cccnc1

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
PVNIIMVLHYAWGP-UHFFFAOYSA-N

Informazioni sul gene

human ... CYP1A2(1544)
rat ... Chrnb2(54239)

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Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H319

Classi di pericolo

Eye Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

379.4 °F - closed cup

Punto d’infiammabilità (°C)

193 °C - closed cup

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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Koon K Teo et al.
Stroke, 44(10), 2688-2693 (2013-07-25)
In Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcomes (AIM-HIGH) trial, addition of extended-release niacin (ERN) to simvastatin in participants with established cardiovascular disease, low high-density lipoprotein cholesterol, and high triglycerides had no incremental
John R Guyton et al.
Journal of the American College of Cardiology, 62(17), 1580-1584 (2013-08-07)
This study sought to examine the relationship between niacin treatment, lipoproteins, and cardiovascular (CV) outcomes in this secondary analysis of the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes) trial. During a
Martina Lukasova et al.
Trends in pharmacological sciences, 32(12), 700-707 (2011-09-29)
Nicotinic acid (niacin) has been used for decades to prevent and treat atherosclerosis. The well-documented antiatherogenic activity is believed to result from its antidyslipidemic effects, which are accompanied by unwanted effects, especially a flush. There has been renewed interest in
Amandine Girousse et al.
PLoS biology, 11(2), e1001485-e1001485 (2013-02-23)
When energy is needed, white adipose tissue (WAT) provides fatty acids (FAs) for use in peripheral tissues via stimulation of fat cell lipolysis. FAs have been postulated to play a critical role in the development of obesity-induced insulin resistance, a
Mattijs M Heemskerk et al.
American journal of physiology. Endocrinology and metabolism, 306(7), E808-E813 (2014-01-30)
The lipid-lowering effect of niacin has been attributed to the inhibition of cAMP production in adipocytes, thereby inhibiting intracellular lipolysis and release of nonesterified fatty acids (NEFA) to the circulation. However, long-term niacin treatment leads to a normalization of plasma
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