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I9783

Monoclonal Anti-Importin α3 antibody produced in rat

Name: Monoclonal Anti-Importin α3 antibody produced in rat
Brand: SIGMA

clone 3D10, purified immunoglobulin, buffered aqueous solution

Sinonimo/i:

Anti-Imp α

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About This Item

Numero MDL:

MFCD06798707

Codice UNSPSC:

12352203

NACRES:

NA.41

Origine biologica

rat

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

3D10, monoclonal

Forma fisica

buffered aqueous solution

PM

antigen ~60 kDa

Reattività contro le specie

mouse, hamster, bovine, canine, rat, human, monkey

tecniche

microarray: suitable
western blot: 2-4 μg/mL using HeLa cell extract

Isotipo

IgG2a

N° accesso UniProt

O00629

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... KPNA4(3840)
mouse ... Kpna4(16649)
rat ... Kpna4(361959)

Immunogeno

recombinant mouse importin α3/Qip1.

Azioni biochim/fisiol

The gene KPNA4 (karyopherin subunit α 4) encodes a 16kDa protein, also referred to as importin α 3 belonging to the family of karyopherins (designated KPNA1 to KPNA4), that participates in the recognition of NLS (nuclear localization signal) sites and dock NLS-containing proteins destined for transport into the nuclear pore complex. It binds to translocon and participates in the sorting of INM (inner nuclear membrane)-directed integral membrane proteins. It associates with nucleoporins and functions in cargo-translocation across the nuclear membrane.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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KPNA4 Mediates Vitamin D-Dependent Inhibition of NF-kB Activity in Swine Epicardial Preadipocytes.

Chen S

Circulation, A12818-A12818 (2014)

Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane.

Matthew Frieman et al.

Journal of virology, 81(18), 9812-9824 (2007-06-29)

The host innate immune response is an important deterrent of severe viral infection in humans and animals. Nuclear import factors function as key gatekeepers that regulate the transport of innate immune regulatory cargo to the nucleus of cells to activate

Early sorting of inner nuclear membrane proteins is conserved.

Sharon C Braunagel et al.

Proceedings of the National Academy of Sciences of the United States of America, 104(22), 9307-9312 (2007-05-23)

Spodoptera frugiperda (Sf9) importin-alpha-16 is a translocon-associated protein that participates in the early sorting pathway of baculovirus integral membrane proteins destined for the inner nuclear membrane (INM). To discern whether sorting intermediate protein complexes like those observed in insect cells

TCF11 at the crossroads of oxidative stress and the ubiquitin proteasome system.

Annett Koch et al.

Cell cycle (Georgetown, Tex.), 10(8), 1200-1207 (2011-03-18)

It is well established that mutual relations exist between the oxidative status of a cell and the ubiquitin proteasome system (UPS). Oxidation of proteins leads to misfolding and thus claims a higher proteolytic activity of the UPS to dispose these

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