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F4765

Fluphenazine dihydrochloride

Name: Fluphenazine dihydrochloride
Brand: SIGMA

Sinonimo/i:

4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol dihydrochloride

Autenticati per visualizzare i prezzi organizzativi e contrattuali.

Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₂₂H₂₆F₃N₃OS · 2HCl

Numero CAS:

146-56-5

Peso molecolare:

510.44

NACRES:

NA.77

PubChem Substance ID:

57654184

UNSPSC Code:

12352200

EC Number:

205-674-1

MDL number:

MFCD00055212

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Proprietà

SMILES string

Cl.Cl.OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1

InChI

1S/C22H26F3N3OS.2ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29;;/h1-2,4-7,16,29H,3,8-15H2;2*1H

InChI key

MBHNWCYEGXQEIT-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812), DRD2(1813), HRH1(3269)

Descrizione

General description

Fluphenazine may be useful for the treatment of schizophrenia.

Application

Fluphenazine dihydrochloride has been used:

to study its effects as a drug on glioblastoma (GBM) cells
in fluorescence-activated cell sorting (FACS) analysis, sorting and single-cell stress-survival experiments
to study its exposure effects on learning and memory in adult rats

Biochem/physiol Actions

D₁/D₂ dopamine receptor antagonist; phenothiazine antipsychotic; H₁ histamine receptor antagonist.

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H360

pcodes

P201 - P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral - Repr. 1A

Classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Inverse agonist properties of dopaminergic antagonists at the D(1A) dopamine receptor: uncoupling of the D(1A) dopamine receptor from G(s) protein.

G Cai et al.

Molecular pharmacology, 56(5), 989-996 (1999-10-26)

The interaction of dopaminergic antagonists with the D(1A) dopamine receptor was assessed in PC2 cells that transiently express this receptor. The maximal binding and dissociation constants for the D(1A) dopamine receptor, using the ligand [(125)I]SCH23982 were 0.38 +/- 0.09 nM

Coupling phenotypic persistence to DNA damage increases genetic diversity in severe stress

Yaakov G, et al.

Nature ecology & evolution, 1(1), 0016-0016 (2017)

Principles of Psychopharmacology for Mental Health Professionals (2006)

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Numero articolo commerciale globale

SKU	GTIN
F4765-1G	04061825982250
F4765-5G	04061832090832

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