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E5641

11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid

Name: 11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid
Brand: SIGMA

~100 μg/mL in ethanol, ≥95%

Sinonimo/i:

(±)11,12-EpETrE, 11,12-EET

Autenticati per visualizzare i prezzi organizzativi e contrattuali.

Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₂₀H₃₂O₃

Numero CAS:

123931-40-8

Peso molecolare:

320.47

NACRES:

NA.25

PubChem Substance ID:

24894343

UNSPSC Code:

12352211

EC Number:

200-578-6

MDL number:

MFCD00132914

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Proprietà

Quality Level

200

assay

≥95%

concentration

~100 μg/mL in ethanol

lipid type

omega FAs

storage temp.

−20°C

SMILES string

CCCCC\C=C\CC1OC1C\C=C\C\C=C\CCCC(O)=O

InChI

1S/C20H32O3/c1-2-3-4-5-9-12-15-18-19(23-18)16-13-10-7-6-8-11-14-17-20(21)22/h6,8-10,12-13,18-19H,2-5,7,11,14-17H2,1H3,(H,21,22)/b8-6+,12-9+,13-10+

InChI key

DXOYQVHGIODESM-ATELOPIESA-N

Descrizione

Packaging

Packaged under argon

pictograms

GHS02,GHS07

signalword

Danger

hcodes

H225,H319

pcodes

P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Classe di stoccaggio

3 - Flammable liquids

wgk

WGK 1

flash_point_f

48.2 °F - closed cup

flash_point_c

9 °C - closed cup

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Contenuto correlato

Data Sheet - E5641

The biological actions of 11,12-epoxyeicosatrienoic acid in endothelial cells are specific to the R/S-enantiomer and require the G(s) protein.

Yindi Ding et al.

The Journal of pharmacology and experimental therapeutics, 350(1), 14-21 (2014-04-26)

Cytochrome P450-derived epoxides of arachidonic acid [i.e., the epoxyeicosatrienoic acids (EETs)] are important lipid signaling molecules involved in the regulation of vascular tone and angiogenesis. Because many actions of 11,12-cis-epoxyeicosatrienoic acid (EET) are dependent on the activation of protein kinase

Soluble Epoxide Hydrolase Inhibitor Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Improves Survival in Mice.

Yong Zhou et al.

Shock (Augusta, Ga.), 47(5), 638-645 (2016-10-19)

Acute lung injury (ALI) is characterized by rapid alveolar injury, vascular leakage, lung inflammation, neutrophil accumulation, and induced cytokines production leading to lung edema. The mortality rate of patients suffering from ALI remains high. Epoxyeicosatrienoic acids (EETs) are cytochrome P450-dependent

The role of epoxyeicosatrienoic acids in the cardiovascular system.

L Yang et al.

British journal of clinical pharmacology, 80(1), 28-44 (2015-02-07)

There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of cardiovascular risk

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Numero articolo commerciale globale

SKU	GTIN
E5641-25UG	04061838070814

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