E0407

Estramustine sodium phosphate

• Sinonimo/i: Estradiol 3-bis(2-chloroethyl)carbamate 17-(dihydrogen phosphate) sodium salt, Estra-1,3,5(10)triene-3,17β-diol 3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate) sodium salt
• Formula empirica (notazione di Hill): C₂₃H₃₀Cl₂NNa₂O₆P
• Numero CAS: 52205-73-9
• Peso molecolare: 564.35
• NACRES: NA.28
• PubChem Substance ID: 329798968
• UNSPSC Code: 51111800
• EC Number: 257-735-7
• MDL number: MFCD00866320
• Form: powder
• Assay: ≥85.0% (HPLC)

Proprietà

• assay: ≥85.0% (HPLC)
• form: powder
• solubility: H₂O: 50 mg/mL
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H][C@]12[C@@]([C@@](CC[C@@H]3OP([O-])([O-])=O)([H])[C@]3(C)CC2)([H])CCC4=C1C=CC(OC(N(CCCl)CCCl)=O)=C4.[Na+].[Na+]
• InChI: 1S/C23H32Cl2NO6P.2Na/c1-23-9-8-18-17-5-3-16(31-22(27)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)32-33(28,29)30;;/h3,5,14,18-21H,2,4,6-13H2,1H3,(H2,28,29,30);;/q;2*+1/p-2/t18-,19-,20+,21+,23+;;/m1../s1
• InChI key: IIUMCNJTGSMNRO-VVSKJQCTSA-L
• Gene Information: human ... ESR2(2100)

Descrizione

Biochem/physiol Actions

Estradiol mustard prodrug which binds estradiol receptors irreversibly. Alkylating compound used as an antineoplastic agent against prostate cancer. Depolymerizes microtubules by binding to microtubule associated proteins (MAPs).

Estradiol mustard prodrug, which binds estradiol receptors irreversibly. Highly effective in treatment of advanced metastatic prostate cancer. Depolymerizes microtubules by binding to microtubule associated proteins (MAPs).

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves