D1916

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside

≥98% (HPLC), powder, RNA synthesis inhibitor

• Sinonimo/i: 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole, 5,6-Dichlorobenzimidazole riboside, DRB
• Formula empirica (notazione di Hill): C₁₂H₁₂Cl₂N₂O₄
• Numero CAS: 53-85-0
• Peso molecolare: 319.14
• UNSPSC Code: 12352200
• eCl@ss: 32151902
• PubChem Substance ID: 24278361
• NACRES: NA.77
• Beilstein/REAXYS Number: 39123
• MDL number: MFCD00036785
• Form: powder

Proprietà

• Nome del prodotto: 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside,
• Quality Segment: 200
• form: powder
• storage temp.: −20°C
• SMILES string: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3cc(Cl)c(Cl)cc23
• InChI: 1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1
• InChI key: XHSQDZXAVJRBMX-DDHJBXDOSA-N
• Gene Information: human ... CSNK2A1(1457), CSNK2B(1460)

Descrizione

Application

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside has been used:

• as an inhibitor of RNA polymerase II in mouse melanoma cells
• for the inhibition of cyclin D1 mRNA synthesis in human prostate epithelial cell lines
• in the inhibition of interleukin-2 gene transcription in Jurkat cells

Biochem/physiol Actions

Inhibitor of RNA synthesis; causes premature termination of transcription. CK2 (casein kinase-2) inhibitor.

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB), a nucleoside analog that halts mRNA synthesis by phosphorylation of the C-terminal domain of RNA polymerase II, making it inactive. It also interferes with the DNA topoisomerase II, may modulate response to cytokines and blocks the human immunodeficiency virus (HIV) via RNA modification. It also inhibits cyclin-dependent kinases (CDKs) 7 and 9 and favors apoptosis in leukemic cells. It may serve as a therapeutic agent in treating cancer.

Features and Benefits

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Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable