Passa al contenuto
Merck
Tutte le immagini(1)

Documenti

D1069

Sigma-Aldrich

Desloratadine

powder, ≥98% (HPLC)

Sinonimo/i:

8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine, Clarinex®

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C19H19ClN2
Numero CAS:
100643-71-8
Peso molecolare:
310.82
Numero MDL:
MFCD00871949
Codice UNSPSC:
12352200
ID PubChem:
329798668
NACRES:
NA.32

Saggio

≥98% (HPLC)

Forma fisica

powder

Solubilità

DMSO: >10 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1

InChI

1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
JAUOIFJMECXRGI-UHFFFAOYSA-N

Informazioni sul gene

human ... HRH1(3269)

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Applicazioni

Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells. It has also been used as an antihistamine mimic in rats and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies.

Azioni biochim/fisiol

Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.

Note legali

Clarinex is a registered trademark of Schering Corp.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

P5514

Pyrilamine maleate salt

C4915

S-(+)-Chlorpheniramine maleate salt

T6764

Triprolidine hydrochloride, ≥99%

L9664

Loratadine, ≥98% (HPLC), powder

F9427

Fexofenadine hydrochloride, >98% (HPLC)

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

390.2 °F - Pensky-Martens closed cup

Punto d’infiammabilità (°C)

199 °C - Pensky-Martens closed cup

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 8

1 of 8

Clemastine fumarate salt ≥98% (HPLC)

Sigma-Aldrich

SML0445

Clemastine fumarate salt

Loratadine United States Pharmacopeia (USP) Reference Standard

USP

1370270

Loratadine

Fexofenadine hydrochloride >98% (HPLC)

Sigma-Aldrich

F9427

Fexofenadine hydrochloride

(±)-Jasmonic acid suitable for plant cell culture, BioReagent, liquid

Sigma-Aldrich

J2500

(±)-Jasmonic acid

Donepezil hydrochloride ≥98% (HPLC)

Sigma-Aldrich

D6821

Donepezil hydrochloride

Z-VAD-FMK solid

Sigma-Aldrich

V116

Z-VAD-FMK

Ferrostatin-1 ≥95% (HPLC)

Sigma-Aldrich

SML0583

Ferrostatin-1

Piperazine ReagentPlus®, 99%

Sigma-Aldrich

P45907

Piperazine

Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels
Villalpando-Rodriguez GE, et al.
Oxidative Medicine and Cellular Longevity, 2019 (2019)
Translational Physiology: Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome
Gasheva OY, et al.
The American Journal of Physiology, 316(1), G217-G217 (2019)
Nicholas Cutrona et al.
ACS infectious diseases, 5(8), 1397-1410 (2019-05-28)
Staphylococcus epidermidis and Staphylococcus aureus are important human pathogens responsible for two-thirds of all postsurgical infections of indwelling medical devices. Staphylococci form robust biofilms that provide a reservoir for chronic infection, and antibiotic-resistant isolates are increasingly common in both healthcare
Exposure-based validation of an in vitro gastrulation model for developmental toxicity assays
Warkus ELL and Marikawa Y
Toxicological Sciences, 157(1), 235-245 (2017)
Faraz Kazmi et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(9), 1294-1302 (2015-07-03)
Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating antihistamine used for the treatment of seasonal allergies and hives. Previously we reported that the formation of 3-hydroxydesloratadine, the major human metabolite of desloratadine, involves three sequential reactions
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.