Solutions may break down during storage. Aqueous solutions can be kept for a few hours at temperatures up to 25 °C. It is recommended that this product be prepared fresh for optimal results.
C7397
Cyclophosphamide monohydrate
ISOPAC®
Sinonimo/i:
2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan
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| A voi/SKU | Disponibilità | Prezzo |
|---|---|---|
1 g | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 241,00 € |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C7H15Cl2N2O2P · H2O
Numero CAS:
Peso molecolare:
279.10
UNSPSC Code:
51112507
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-015-4
Beilstein/REAXYS Number:
4678992
MDL number:
Assay:
97.0-103.0% (HPLC)
Form:
powder
241,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Servizio Tecnico
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Permettici di aiutartiQuality Segment
assay
97.0-103.0% (HPLC)
form
powder
mp
49-51 °C (lit.)
storage temp.
2-8°C
SMILES string
[H]O[H].ClCCN(CCCl)P1(=O)NCCCO1
InChI
1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2
InChI key
PWOQRKCAHTVFLB-UHFFFAOYSA-N
Application
Cyclophosphamide, a nitrogen mustard DNA alkylating agent, is used to study its mechanisms of action as an anticancer and antiimmunity drug.
Biochem/physiol Actions
Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
Cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations.
Packaging
Packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal.
Preparation Note
Dissolving the contents in 100 mL of solvent yields a 1% solution.
Legal Information
Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Injecting a compatible solvent directly into the vial permits preparation of any desired strength solution without exposure.
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Questo articolo | |||
|---|---|---|---|
| assay 97.0-103.0% (HPLC) | assay - | assay 97.0-103.0% (HPLC) | assay ≥98.0% (HPLC) |
| form powder | form crystalline | form powder | form - |
| Quality Level 100 | Quality Level - | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| mp 49-51 °C (lit.) | mp 49-51 °C (lit.) | mp 49-51 °C (lit.) | mp 47-52 °C, 49-51 °C (lit.) |
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Explore all of our products under Cyclophosphamide monohydrate
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 1B - Muta. 1B - Repr. 1A
Classe di stoccaggio
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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I dissolved this product in PBS for intraperitoneal injections. The storage conditions are the same for PBS? You previously said that the the stock solution should be stored at 0 - 4°C for short-term, how long is short-term use? Thanks
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfUtile?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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How should stock solutions for item C7397-1G, Cyclophosphamide monohydrate be stored?
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The stock solution should be stored at 0 - 4°C for short-term use or at -20°C for long-term storage.
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what is the difference between C7397 & C0768?
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Both Product C7397 and C0768 fall under the same Chemical Abstract Service number (CAS) 6055-19-2, which means chemically they are the same. Both products are also offered in a powdered format. These products are suitable for the application of cyclophosphamide.
The differences between the two materials is that product C7397 is only offered in 1 gram pack size. It is also apart of the ISOPAC portfolio, which are products that are packaged in special packaging for sensitive and hazardous chemical. This product is specifically packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal. This specialized packaging allows for injection of a compatible solvent directly into the vial to any desired strength solution without exposure of the material to the air. Product C0768 is offered in 1 gram, 5 grams, 10 grams, and 25 grams. All pack sizes are packaged in a glass bottle and bulk packaging is an available option for this material.
Product C7397 has a quality level of 100 while product C0768 has a quality level of 200. Products with quality level 100 are designed for non-regulated applications with no change notification requirements. Products with quality level of 200 are designed for non-regulated applications with limited change notification requirements.
The specifications for each product are slightly different as well, please view the specification sheets for both items:
https://www.sigmaaldrich.com/specification-sheets/473/595/C7397-BULK________SIGMA____.pdf
https://www.sigmaaldrich.com/specification-sheets/989/258/C0768-BULK________SIGMA____.pdfUtile?
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