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Merck

C1997

CYM-5442

≥98% (HPLC)

Sinonimo/i:

2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol

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Informazioni su questo articolo

Formula empirica (notazione di Hill):
C23H27N3O4
Numero CAS:
1094042-01-9
Peso molecolare:
409.48
NACRES:
NA.77
PubChem Substance ID:
329774920
UNSPSC Code:
12352211
MDL number:
MFCD12912402
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100

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Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: >5 mg/mL

storage temp.

−20°C

SMILES string

CCOc1ccc(cc1OCC)-c2nc(no2)-c3cccc4C(CCc34)NCCO

InChI

1S/C23H27N3O4/c1-3-28-20-11-8-15(14-21(20)29-4-2)23-25-22(26-30-23)18-7-5-6-17-16(18)9-10-19(17)24-12-13-27/h5-8,11,14,19,24,27H,3-4,9-10,12-13H2,1-2H3

InChI key

NUIKTBLZSPQGCP-UHFFFAOYSA-N

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Questo articolo
SML2384SML0501SML1883
CYM-5442 ≥98% (HPLC)

Sigma-Aldrich

C1997

CYM-5442

BAY 87-2243 ≥98% (HPLC)

Sigma-Aldrich

SML2384

BAY 87-2243

SB-590885 ≥98% (HPLC)

Sigma-Aldrich

SML0501

SB-590885

AR231453 ≥98% (HPLC)

Sigma-Aldrich

SML1883

AR231453

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: >5 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL (clear solution, warmed)

solubility

DMSO: 20 mg/mL, clear

Biochem/physiol Actions

CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist that activates S1P1-dependent pathways in vitro and to levels of full efficacy in vivo through a hydrophobic pocket, separable from the orthosteric site of S1P binding that is headgroup dependent. This is a different site from those involved in the activities of other agonists such as FTY720 and SEW2871.
CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist that activates S1P1-dependent pathways in vitro and to levels of full efficacy in vivo.

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000081567
0000054293
0000054294
0000052825
039K46072

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Román Blanco et al.
Experimental eye research, 164, 37-45 (2017-08-23)
We investigated the feasibility and efficacy of using a specific sphingosine 1-phosphate (S1P1) receptor agonist, CYM-5442, to slow or block retinal ganglion cell (RGC) loss in endothelin-1 (ET-1) induced RGC loss. A single intravitreal injection of ET-1 (20pmol/ul), a potent
Xiaochen Wang et al.
Immunity, 56(1), 58-77 (2022-12-16)
Obesity-induced chronic liver inflammation is a hallmark of nonalcoholic steatohepatitis (NASH)-an aggressive form of nonalcoholic fatty liver disease. However, it remains unclear how such a low-grade, yet persistent, inflammation is sustained in the liver. Here, we show that the macrophage
Alena Chumanevich et al.
Mediators of inflammation, 2016, 1503206-1503206 (2016-02-18)
Mast cells (MC) are present in most vascularized tissues around the vasculature likely exerting immunomodulatory functions. Endowed with diverse mediators, resident MC represent first-line fine-tuners of local microenvironment. Sphingosine-1-phosphate (S1P) functions as a pluripotent signaling sphingolipid metabolite in health and
Emily Crowley et al.
The FEBS journal, 287(22), 4917-4932 (2020-03-05)
Autophagy plays a role in several human diseases, but each of the current methods to measure autophagy has significant drawbacks. ATG5 and ATG16L1 are regulators necessary for autophagy; therefore, drugs that inhibit the interaction of these proteins may be therapeutically
Léa M M Costes et al.
PloS one, 9(7), e102211-e102211 (2014-07-11)
Postoperative ileus is characterized by a transient impairment of the gastrointestinal motility after abdominal surgery. The intestinal inflammation, triggered by handling of the intestine, is the main factor responsible for the prolonged dysmotility of the gastrointestinal tract. Secondary lymphoid organs

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Numero articolo commerciale globale

SKUGTIN
C1997-25MG04061833217924
C1997-5MG04061833217931

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